Figure 3. KEGG pathway enrichment analysis. The X-axis shows the reporter score, and a score exceeding the dashed vertical line indicates that the pathway was enriched in the group. (A) The pentose and glucuronate interconversion, fructose and mannose metabolism, and galactose metabolism pathways were enriched in the periodontitis state. (B) The PTS, lipopolysaccharide and peptidoglycan biosynthesis, and glycolysis pathways were enriched in the T2D state. (C) The pentose and glucuronate interconversion, fructose and mannose metabolism, galactose metabolism, ABC transporter and PTS pathways were enriched in the T2D complicated with periodontitis state. (D) The PTS, bacterial secretion system, and sulfur metabolism pathways were enriched in the T2D complicated with periodontitis state compared with the periodontitis state. (E) The pentose and glucuronate interconversion, fructose and mannose metabolism, and amino acid biosynthesis pathways were enriched in the T2D complicated with periodontitis state compared with those in the T2D state.

KEGG: Kyoto Encyclopedia of Genes and Genomes, T2D: type 2 diabetes mellitus, P: periodontitis, PTS: phosphotransferase system.