Table 2. The main driver species in different disease states.

Shift in the disease state	Main driver species
T2D−P− to T2D−P+	Desulfatirhabdium, Longilinea, Cytophaga, Thermocrinis, Pseudomonas, Geobacillus, Shuttleworthia, Cyclobacterium, Intrasporangium, Sagittula, Flaviflexus, Blastococcus, Alysiella, Finegoldia
T2D−P− to T2D+P−	Leptolinea, Sagittula, Pseudomonas, Flaviflexus, Sinomonas
T2D−P− to T2D+P+	Ochrobactrum, Chloroflexus, Halolamina
T2D−P+ to T2D+P+	Ochrobactrum, Chloroflexus
T2D+P− to T2D+P+	Ochrobactrum, Chloroflexus, Halolamina

T2D: type 2 diabetes mellitus, P: periodontitis.