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. 2022 Jul 13;13(17):2539–2541. doi: 10.1111/1759-7714.14580

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© 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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(a) Lymphoepithelial carcinoma (LEC) shows the sheet of poorly differentiated squamous cell carcinoma. The tumor shows a sheet of spindle‐shaped cells with eosinophilic cytoplasm and basophilic nuclei (asterisk) with some lymphocyte infiltrate accompanied by surrounding lymphoplasmacytic stroma (arrow) (hematoxylin–eosin, original magnification ×400). (b) p40 immunohistochemistry in LEC. The tumor cells show diffuse and strong nuclear p40 staining indicating squamous differentiation (original magnification ×400). (c) Epstein–Barr virus (EBV)‐encoded small RNA (EBER) in situ hybridization in LEC. EBER is diffusely positive in the tumor cells (original magnification ×400). (d) Low expression of PD‐L1 (22C3) immunohistochemistry in LEC. The tumor cells show faint incomplete membrane staining of the PD‐L1 staining (original magnification ×600)