TABLE 1.
TOP 30 GO functional enrichment analysis of four potential biomarkers and their interacting genes in LUAD
| GO | Category | Description | p‐value | Count |
|---|---|---|---|---|
| GO:0032480 | GO biological processes | Negative regulation of type I interferon production | 3.32857E‐12 | 7 |
| GO:0043161 | GO biological processes | Proteasome‐mediated ubiquitin‐dependent protein catabolic process | 1.55751E‐11 | 12 |
| GO:0010498 | GO biological processes | Proteasomal protein catabolic process | 6.99509E‐11 | 12 |
| GO:1903052 | GO biological processes | positive regulation of proteolysis involved in cellular protein catabolic process | 7.59907E‐11 | 8 |
| GO:0032479 | GO biological processes | Regulation of type I interferon production | 1.1264E‐10 | 8 |
| GO:0032606 | GO biological processes | Type I interferon production | 1.27871E‐10 | 8 |
| GO:1903364 | GO biological processes | Positive regulation of cellular protein catabolic process | 2.62631E‐10 | 8 |
| GO:0045732 | GO biological processes | Positive regulation of protein catabolic process | 2.71839E‐10 | 9 |
| GO:0032648 | GO biological processes | Regulation of interferon‐beta production | 4.57194E‐10 | 6 |
| GO:0032608 | GO biological processes | Interferon‐beta production | 5.90346E‐10 | 6 |
| GO:2000060 | GO biological processes | Positive regulation of ubiquitin‐dependent protein catabolic process | 6.41312E‐10 | 7 |
| GO:1901800 | GO biological processes | Positive regulation of proteasomal protein catabolic process | 1.21734E‐09 | 7 |
| GO:0000209 | GO biological processes | Protein polyubiquitination | 7.06565E‐09 | 9 |
| GO:1903050 | GO biological processes | Regulation of proteolysis involved in cellular protein catabolic process | 7.58462E‐09 | 8 |
| GO:0032436 | GO biological processes | Positive regulation of proteasomal ubiquitin‐dependent protein catabolic process | 1.15354E‐08 | 6 |
| GO:2000058 | GO biological processes | Tegulation of ubiquitin‐dependent protein catabolic process | 1.50784E‐08 | 7 |
| GO:1903362 | GO biological processes | Regulation of cellular protein catabolic process | 2.32282E‐08 | 8 |
| GO:0045862 | GO biological processes | Positive regulation of proteolysis | 2.45604E‐08 | 9 |
| GO:0042176 | GO biological processes | Regulation of protein catabolic process | 4.19396E‐08 | 9 |
| GO:0061136 | GO biological processes | Regulation of proteasomal protein catabolic process | 6.22337E‐08 | 7 |
| GO:0016579 | GO biological processes | Protein deubiquitination | 6.65789E‐08 | 8 |
| GO:0070646 | GO biological processes | Protein modification by small protein removal | 1.0164E‐07 | 8 |
| GO:0009896 | GO biological processes | Positive regulation of catabolic process | 1.06644E‐07 | 9 |
| GO:0000151 | GO cellular components | Ubiquitin ligase complex | 2.67001E‐08 | 8 |
| GO:0004842 | GO molecular functions | Ubiquitin‐protein transferase activity | 3.61547E‐19 | 17 |
| GO:0019787 | GO molecular functions | Ubiquitin‐like protein transferase activity | 1.05714E‐18 | 17 |
| GO:0061630 | GO molecular functions | Ubiquitin protein ligase activity | 5.77594E‐13 | 11 |
| GO:0061659 | GO molecular functions | Ubiquitin‐like protein ligase activity | 8.94046E‐13 | 11 |
| GO:0031625 | GO molecular functions | Ubiquitin protein ligase binding | 2.82069E‐10 | 10 |
| GO:0044389 | GO molecular functions | Ubiquitin‐like protein ligase binding | 5.06901E‐10 | 10 |