TABLE 2.
The treatment effect for all the evaluated treatment options
| a. Overall survival | ||||
|---|---|---|---|---|
| NCRT + S | NCT + S | NRT + S | S | |
| NCRT + S | NCRT + S | 1.15 (0.98, 1.35) | 1.1 (0.83, 1.45) | 1.29 (1.14, 1.47) |
| NCT + S | 0.87 (0.74, 1.02) | NCT + S | 0.96 (0.71, 1.25) | 1.11 (0.98, 1.28) |
| NRT + S | 0.91 (0.69, 1.21) | 1.04 (0.8, 1.4) | NRT + S | 1.17 (0.91, 1.53) |
| S | 0.78 (0.68, 0.88) | 0.9 (0.78, 1.02) | 0.86 (0.65, 1.1) | S |
| b. Progression‐free survival or disease‐free survival | ||||
|---|---|---|---|---|
| NCRT + S | NCT + S | S | ||
| NCRT + S | NCRT + S | 1.14 (0.95, 1.38) | 1.4 (1.24, 1.58) | |
| NCT + S | 0.88 (0.73, 1.06) | NCT + S | 1.23 (1.03, 1.46) | |
| S | 0.72 (0.63, 0.81) | 0.81 (0.69, 0.97) | S | |
| c. Postoperative mortality | ||||
|---|---|---|---|---|
| NCRT + S | NCT + S | NRT + S | S | |
| NCRT + S | NCRT + S | 0.51 (0.28, 0.9) | 0.41 (0.11, 1.49) | 0.57 (0.35, 0.92) |
| NCT + S | 1.96 (1.11, 3.51) | NCT + S | 0.81 (0.22, 2.93) | 1.11 (0.72, 1.76) |
| NRT + S | 2.42 (0.67, 8.79) | 1.23 (0.34, 4.49) | NRT + S | 1.37 (0.38, 4.98) |
| S | 1.77 (1.09, 2.82) | 0.9 (0.57, 1.39) | 0.73 (0.2, 2.61) | S |
| d. Postoperative morbidity | ||||
|---|---|---|---|---|
| NCRT + S | NCT + S | NRT + S | S | |
| NCRT + S | NCRT + S | 0.91 (0.58, 1.42) | 0.74 (0.29, 1.9) | 0.85 (0.56, 1.28) |
| NCT + S | 1.1 (0.7, 1.72) | NCT + S | 0.81 (0.32, 2.08) | 0.93 (0.62, 1.42) |
| NRT + S | 1.36 (0.53, 3.41) | 1.23 (0.48, 3.12) | NRT + S | 1.15 (0.45, 2.91) |
| S | 1.18 (0.78, 1.77) | 1.07 (0.7, 1.61) | 0.87 (0.34, 2.2) | S |
| e. Locoregional recurrence | ||||
|---|---|---|---|---|
| NCRT + S | NCT + S | NRT + S | S | |
| NCRT + S | NCRT + S | 1.47 (0.86, 2.43) | 0.9 (0.27, 3) | 2.06 (1.35, 3.22) |
| NCT + S | 0.68 (0.41, 1.16) | NCT + S | 0.61 (0.19, 2.09) | 1.41 (0.9, 2.32) |
| NRT + S | 1.12 (0.33, 3.66) | 1.63 (0.48, 5.4) | NRT + S | 2.3 (0.76, 7.05) |
| S | 0.49 (0.31, 0.74) | 0.71 (0.43, 1.12) | 0.43 (0.14, 1.32) | S |
| f. Distant metastases | ||||
|---|---|---|---|---|
| NCRT + S | NCT + S | NRT + S | S | |
| NCRT + S | NCRT + S | 1.6 (1.11, 2.21) | 1.38 (0.64, 3.03) | 1.5 (1.13, 1.98) |
| NCT + S | 0.63 (0.45, 0.9) | NCT + S | 0.87 (0.4, 1.95) | 0.94 (0.7, 1.3) |
| NRT + S | 0.72 (0.33, 1.57) | 1.15 (0.51, 2.5) | NRT + S | 1.08 (0.52, 2.22) |
| S | 0.67 (0.51, 0.88) | 1.07 (0.77, 1.43) | 0.92 (0.45, 1.92) | S |
Note: Statistically confident results are in bold.
Abbreviations: NCRT + S, neoadjuvant chemoradiotherapy followed by surgery; NCT + S, neoadjuvant chemotherapy followed by surgery; NRT + S, neoadjuvant radiotherapy followed by surgery; S, surgery.