Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model of PKM2 regulation by OGT upon EGF stimulation. EGF stimulates the phosphorylation of OGT at Y976 to promote its association with PKM2. As a consequence, PKM2 are O-GlcNAcylated at T405/S406, resulting in the disassembly of active tetramers into less active dimers and monomers. EGF, epidermal growth factor; OGT, O-GlcNAc transferase.
