Table 4.
In vitro antifungal susceptibilities of dermatophyte isolates obtained from hedgehogs
| Antifungal agents | MIC (µg/ml) | Dermatophyte species | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Trichophyton erinacei | Trichophyton mentagrophytes | Trichophyton benhamiae | Microsporum canis | Nannizzia gypsea | Nannizzia nana | Paraphyton cookei | Nannizzia fulva* | ||||
| Allylamine | NFT | MIC50 | 0.016 | 0.008 | 0.004 | 0.032 | 0.25 | 0.032 | 0.25 | 0.032 | |
| MIC90 | 0.032 | 0.016 | 0.016 | 0.064 | 0.25 | 0.032 | 0.5 | ||||
| TRB | MIC50 | 0.004 | 0.008 | (2) | 0.008 | 0.016 | 0.0125 | 0.032 | 0.0125 | 0.032 | |
| MIC90 | 0.0016 | 2 | 0.032 | 0.016 | 0.25 | 0.064 | 0.032 | ||||
| Polyenes | AMB | MIC50 | 0.25 | 0.25 | 0.125 | 0.25 | 0.064 | 0.125 | 0.25 | 0.5 | |
| MIC90 | 0.25 | 0.5 | 0.25 | 1 | 0.25 | 0.5 | 0.5 | ||||
| Non-polyenes | GRE | MIC50 | 1 | 1 | 0.5 | 0.25 | 0.5 | 0.25 | 1 | 0.5 | |
| MIC90 | 1 | 2 | 1 | 1 | 0.5 | 1 | 2 | ||||
| Imidazoles | KTC | MIC50 | 0.5 | 0.5 | 0.25 | 0.125 | 0.125 | 1 | 0.5 | 0.5 | |
| MIC90 | 0.5 | 2 | 0.5 | 0.5 | 0.125 | 1 | 1 | ||||
| MCZ | MIC50 | 0.032 | 0.064 | 0.016 | 0.032 | 0.064 | 0.5 | 0.125 | 0.064 | ||
| MIC90 | 0.125 | 0.125 | 0.125 | 0.064 | 0.125 | 2 | 0.25 | ||||
| ENC | MIC50 | 0.125 | 0.25 | 0.064 | 0.032 | 0.5 | 0.5 | 0.25 | 0.032 | ||
| MIC90 | 0.25 | 2 | 0.25 | 0.125 | 1 | 0.5 | 1 | ||||
| LUC | MIC50 | 0.004 | 0.004 | 0.016 | 0.008 | 0.016 | 0.008 | 0.016 | 0.008 | ||
| MIC90 | 0.016 | 0.008 | 0.032 | 0.016 | 0.064 | 0.064 | 0.016 | ||||
| Triazoles | ITC | MIC50 | 0.25 | 0.5 | 0.125 | 0.125 | 0.25 | 0.125 | 0.25 | 0.25 | |
| MIC90 | 1 | 2 | 0.25 | 1 | 0.5 | 1 | 1 | ||||
| FLC | MIC50 | 16 | 32 | 16 | 16 | 8 | 4 | 8 | 64 | ||
| MIC90 | 32 | 64 | 64 | 16 | 16 | 16 | 32 | ||||
| VRC | MIC50 | 0.032 | 0.016 | 0.032 | 0.064 | 0.016 | 0.125 | 0.25 | 0.125 | ||
| MIC90 | 0.125 | 0.064 | 0.25 | 0.125 | 0.064 | 0.5 | 1 | ||||
| Pyridinone derivatives | CPO | MIC50 | 0.064 | 0.016 | 0.032 | 0.25 | 0.016 | 0.032 | 0.064 | 0.032 | |
| MIC90 | 0.064 | 0.032 | 0.064 | 0.5 | 0.064 | 0.032 | 0.064 | ||||
| Phenyl morpholine derivatives | AMR | MIC50 | 0.008 | 0.016 | 0.008 | 0.016 | 0.032 | 0.008 | 0.016 | 0.016 | |
| MIC90 | 0.016 | 0.064 | 0.008 | 0.032 | 0.032 | 0.008 | 0.016 | ||||
Notes: abbreviations of antifungal substances: AMB, amphotericin B; AMR, amorolfine; CPO, ciclopirox; ENC, enilconazole; FLC, fluconazole; GRE, griseofulvin; ITC, itraconazole; KTC, ketoconazole; LUC, luliconazole; MCZ, miconazole; NFT, naftifine; TRB, terbinafine; VRC, voriconazole; (n), number of strains that showed resistance to terbinafine (MIC = 2 µg/ml); STstatistically significantly the lowest result in human/animals group; *the result presented for the two obtained isolates