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Mutations of B.1.1.7Alpha, Epsilon/B.1.427/B.1.429
(A) lose binding and neutralization owing to E484K and K417N; deficiency of salt bridges between Lys417 and ACE2 Asp30 and between Glu484 and ACE2 Lys31.
(B) S mutations of B.1.427 and B.1.429, including signal peptides S13I, NTD W152C, and RBD L452R.
