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Immune escape mechanism of B.1.1.7Alpha
(A) N501Y mutation in the B.1.1.7 variant can perform immune escape by disrupting antibody binding.
(B) B.1.1.7 boosted the expression of Orf6 and Orf9 and the innate immune response is suppressed by Orf9b expression alone and its interaction with TOM70. Upregulation of Orf6, and Orf9b has contributed to an increased ability of immune evasion.
