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. 2022 Jun 23;55(9):e13250. doi: 10.1111/cpr.13250

FIGURE 4.

FIGURE 4

High salt induces pro‐inflammatory Treg cells. (A) High salt enables murine and human Treg cells to acquire a Th1‐like phenotype. High salt enhances the phosphorylation of FOXO1/FOXO3 by activating SGK1, followed by decreased Foxp3 stability and increased IFN‐γ secretion. (B) High salt can induce Th17‐like Treg cells. High salt can enhance TGF‐β‐mediated Treg cell induction while facilitating the co‐expression of RORγt