TABLE 1.
The effect of high‐salt diet on immune‐regulated diseases in mouse models
| Disease | Effect | Responses | References |
|---|---|---|---|
| Hypertension | Increased | ↑MPS cells | 46 |
| ↑DCs | 110 | ||
| ↑Th17 cells and IL‐17 | 130 | ||
| ↓Lactobacillus spp. | 130 | ||
| Actively induced EAE | Exacerbated | ↑Th17 cells | 130 |
| ↓Lactobacillus spp. | 130 | ||
| ↑Pro‐inflammatory myeloid cells | 45 | ||
| ↑Blood–brain barrier permeability | 141 | ||
| Spontaneous EAE | Suppressed | ↓Blood–brain barrier permeability | 142 |
| Experimental colitis | Exacerbated | ↑Macrophages | 143, 144, 145 |
| ↑Th17 cells and ILC3 | 131, 146, 147 | ||
| ↓Treg cells | 132 | ||
| ↓Lactobacillus spp. and butyrate | 131 | ||
| ↑Intestinal fibroblasts | 148 | ||
| Systemic lupus erythematosus | Exacerbated | ↑Th1 and Th17 cells | 149 |
| ↑Tfh cells | 62 | ||
| ↑DCs | 112 | ||
| Collagen‐induced arthritis | Exacerbated | ↑Th17 cells and IL‐17 | 150 |
| No significant influence | / | 151 | |
| K/BxN serum transfer‐induced arthritis | No significant influence | / | 151 |
| Cancer | Exacerbated | ↑Th17 cells and IL‐17 | 152 |
| ↑Helicobacter pylori infection | 153 | ||
| Inhibited | ↓MDSCs | 154, 155 | |
| ↑T cells | 154 | ||
| ↑Bifidobacterium and NK cross‐talk | 86 | ||
| Infection | Exacerbated | ↓Neutrophils | 82 |
| Prevented | ↑M1 and ↓M2 macrophages | 41, 97, 156, 157 | |
| Ischemic stroke | Aggravated | ↑Blood–brain barrier disruption | 158 |
| ↑M1 and ↓M2 macrophages | 159, 160 | ||
| Cognitive disorders | Impaired | ↑Th17 cells and IL‐17 | 161 |
| ↑M1 microglia | 162 | ||
| Wound healing | Delayed | ↓M2 macrophages | 56 |
| Acute renal failure | Aggravated | ↑Th17 cells | 163, 164 |
| Transplantation rejection | Accelerated | ↓Treg cells | 55, 132 |
| Osteopenia | Increased | ↑Th17 cells and ↓Treg cells | 165 |
↑: increased; ↓: decreased.