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. 2022 Sep 1;12:14883. doi: 10.1038/s41598-022-19245-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Brown adipose tissue dysfunction deteriorates cardiac function after TAC. (A) Hematoxylin and eosin (HE) staining of BAT from 8-week-old littermate control (WT) mice or BAT-specific Mfn1/Mfn2 DKO (BAT Mfn DKO) mice. Scale bar = 500 μm. (B) Body temperature of mice at 2 weeks after TAC (n = 4, 4). (C) Cumulative survival rate of mice at 1 week after TAC (n = 49, 49). (D) Assessment of cardiac function in the indicated mice at 1 week after Sham or TAC (FS; n = 5, 4, 28, 16, LVDs; n = 5, 4, 28, 16). (E) Quantification of TUNEL-positive cardiomyocytes in the hearts of mice at 1 week after TAC (n = 4, 4). (F) Masson’s trichrome staining of hearts from the mice. The right panel shows quantification of the fibrotic area (n = 13, 10, 21, 13). Scale bar = 50 μm. Data were analysed by the 2-tailed Student’s t-test (B, E), 2-way ANOVA followed by Dunnett’s comparison test (D), or the log-rank test for Kaplan–Meier method (C). *P < 0.05, **P < 0.01. Values are shown as the mean ± s.e.m.