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. 2022 Sep 1;12:14902. doi: 10.1038/s41598-022-19065-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Dietary 7-KC increased the infarct size after myocardial IR through monocyte/macrophage-mediated inflammation. (A) Infarct size at 24 h after IR. Scale bar, 1 mm. N = 8–10. The data were analyzed by one-way ANOVA, followed by Tukey’s post-hoc multiple comparison test. (B) Macrophages (Mac-3-positive cells) in the heart at 24 h after IR. Scale bar, 20 µm. N = 7. The data were analyzed by one-way ANOVA, followed by Tukey’s post-hoc multiple comparison test. (C) Percentages of Ly-6C-high or Ly-6C-low monocytes/macrophages in the heart at 24 h after IR assessed by flow cytometry. N = 6. The data were analyzed by chi-square test. (D) Infarct size in WT and CCR2-deficient mice at 24 h after IR. The data of WT group was cited from (A) as the control. N = 6. The data were analyzed by one-way ANOVA, followed by Tukey’s post-hoc multiple comparison test. ND, normal laboratory diet; WD, Western diet; 7KWD, WD containing 7-KC; AAR, area at risk; IR, ischemia–reperfusion; Lin, lineage; Mo, monocyte; Mph, macrophage; CCR2^−/−, CCR2-deficient mice; WT, wild-type mice.