Table 1.
Plasma lipid parameters.
| Lipid profiles | |||
|---|---|---|---|
| ND (N = 6) |
WD (N = 6) |
7KWD (N = 6) |
|
| Total cholesterol (mg/dL) | 93 ± 5 | 160 ± 4*** | 150 ± 8*** |
| LDL cholesterol (mg/dL) | 20 ± 1 | 37 ± 2*** | 36 ± 1*** |
| HDL cholesterol (mg/dL) | 54 ± 2 | 41 ± 3** | 44 ± 2* |
| Triglyceride (mg/dL) | 84 ± 8 | 23 ± 1*** | 27 ± 4*** |
| Oxysterols | |||
|---|---|---|---|
| ND (N = 8) |
WD (N = 8) |
7KWD (N = 8) |
|
| 7α-hydroxycholesterol | 8.9 ± 3.7 | 41.1 ± 15.1 | 17.3 ± 6.4 |
| 7β-hydroxycholesterol | 54.0 ± 20.1 | 149.8 ± 29.9 | 1168.0 ± 241.6***†† |
| 7-ketocholesterol | 64.5 ± 12.5 | 144.7 ± 31.7 | 399.4 ± 61.9***†† |
| 5β,6β-epoxycholesterol | 14.3 ± 8.5 | 43.5 ± 11.6 | 31.2 ± 6.4 |
| 4β-hydroxycholesterol | 79.0 ± 9.6 | 385.6 ± 69.2** | 457.7 ± 77.4*** |
| cholestan-3β,5α,6β-triol | 0.1 ± 0.0 | 0.3 ± 0.1 | 0.3 ± 0.2 |
| 24-hydroxycholesterol | 3.9 ± 1.3 | 11.6 ± 3.3 | 25.6 ± 4.4***† |
| 25-hydroxycholesterol | 18.3 ± 5.2 | 13.6 ± 3.0 | 17.5 ± 2.9 |
| 27-hydroxycholesterol | 22.3 ± 6.2 | 53.1 ± 11.0* | 56.3 ± 6.1* |
| Total oxysterols | 480 ± 61 | 1067 ± 113 | 2391 ± 299***†† |
Cholesterol and triglyceride levels are shown in mg/dL. The level of each oxysterol component is shown in ng/mL. Data are expressed as the mean ± SEM and were compared using one-way ANOVA with the post hoc Tukey HSD test. *p < 0.05, **p < 0.01, and ***p < 0.001 versus the ND group. †p < 0.05, and ††p < 0.001 versus the WD group. ND, normal laboratory diet; WD, Western diet; 7KWD, WD containing 7-KC.