Table 2.
Potential protein targets of L. camara constituents.
| Target protein short name | Full name of protein | Interacting compound (s) (combined interaction score) |
|---|---|---|
| APP | Amyloid-beta precursor protein | Myricetin (1), ferulic acid (0.79), isoferulic acid (0.67), chlorogenic acid (0.83), pectolinarigenin (0.53) |
| BCL2 | Apoptosis regulator Bcl-2 | Catechin gallate (1) |
| BRAF | Serine/threonine-protein kinase B-raf | Myricetin (1) |
| CD81 | CD81 antigen | Lantoic acid (0.49), pomolic acid (0.57), 3β,22β)-form, 3-O-(3-methyl-2-butenoyl) (0.64), dihydrorehmannic acid (0.65), lantadene C (0.47), 3,24-dihydroxy-12-ursen-28-oic acid; 3 β form, 3-ketone (0.42), lantanolic acid (0.43), pomonic acid (0.4), icterogenin (0.45), lantanillic acid (0.42), camaric acid (0.41), lantacin (0.51), 3,24-dihydroxy-12-oleanen-28-oic acid; 3α form, 3-ketone, 24-aldehyde (0.49), 3,22-dihydroxy-12-oleanen-28-oic acid; (3 β,22 β)-form, 3-ketone, 22-angeloyl (0.47), 3,22-dihydroxy-12-oleanen-28-oic acid; (3 β, 22 β)-form, 3-ketone, 22-(3-methyl-2-butenoyl) (0.49) |
| CREB1 | Cyclic AMP-responsive element-binding protein 1 | Pectolinarin (0.42), linaroside (0.47), pectolinarigenin (0.79), penduletin (0.4) |
| CXCL12 | Stromal cell-derived factor 1 | Ferulic acid (0.69), isoferulic acid (0.53) |
| FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Myricetin (1) |
| FOS | Proto-oncogene c-Fos | Ferulic acid (0.74), isoferulic acid (0.56) |
| IL2 | Interleukin-2 | Scoparin (0.5), pectolinarin (0.47), narcissin (0.4), 8-epiloganin (0.42), chrysoeriol-7-O-GLUCOSIDE (0.81), linaroside (0.6), rhamnocitrin-O-GLUCOSIDE (0.57) |
| INSR | Insulin receptor | Myricetin (1) |
| JUN | Transcription factor AP-1 | Ferulic acid (0.7) |
| KIT | Mast/stem cell growth factor receptor Kit | Pectolinarigenin (1) |
| LPAR1 | Lysophosphatidic acid receptor 1 | Linoleic acid methyl ester (0.48), Linolenic acid (0.43), myristoleic acid (0.47) |
| LPAR2 | Lysophosphatidic acid receptor 2 | Arachidic acid (0.4), behenic acid (0.4), linoleic acid methyl ester (0.48), Linolenic acid (0.43), myristoleic acid (0.47) |
| LPAR3 | Lysophosphatidic acid receptor 3 | Arachidic acid (0.4), behenic acid (0.4), linoleic acid methyl ester (0.48), Linolenic acid (0.43), myristoleic acid (0.47) |
| LPAR4 | Lysophosphatidic acid receptor 4 | Linoleic acid methyl ester (0.48), myristoleic acid (0.41) |
| MAPK14 | Mitogen-activated protein kinase 14 | Catechin gallate (1) |
| MAPT | Microtubule-associated protein tau | Ferulic acid (0.69), isoferulic acid (0.67), myricetin (1) |
| MET | Hepatocyte growth factor receptor | Catechin gallate (1) |
| MMP9 | Matrix metalloproteinase-9 | Ferulic acid (0.74), isoferulic acid (0.64) |
| PGF | Placenta growth factor | Afzelechin (0.59) |
| PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Myricetin (1) |
| PLA2G2C | Putative inactive group IIC secretory phospholipase A2 | Arachidic acid (0.52), behenic acid (0.52), myristoleic acid (0.43) |
| PLA2G4B | Cytosolic phospholipase A2 beta | Arachidic acid (0.46), behenic acid (0.46) |
| PLA2G5 | Calcium-dependent phospholipase A2 | Arachidic acid (0.43), behenic acid (0.43) |
| PPARA | Peroxisome proliferator-activated receptor alpha | Arachidic acid (1), behenic acid (1) |
| PRKCA | Protein kinase c alpha | Linoleic acid methyl ester (0.51), verbascoside (1) |
| PTGER2 | Prostaglandin E2 receptor EP2 subtype | Arachidic acid (0.45), behenic acid (0.45), ferulic acid (0.44), isoferulic acid (0.44) |
| PTPN1 | Tyrosine-protein phosphatase non-receptor type 1 |
3,22-Dihydroxy-12-oleanen-28-oic acid; 3 β,22 β form, 3-ketone, 22-(3-methyl-2-butenoyl) (0.61), 3,22-dihydroxy-12-oleanen-28-oic acid; (3 β,22 β)-form, 3-ketone, 22-angeloyl (0.61), 3,24-dihydroxy-12-oleanen-28-oic acid; 3α;-form, 3-ketone, 24-aldehyde (0.79), 3,24-dihydroxy-12-ursen-28-oic acid; 3 β-form, 3-ketone (0.64), camaric acid (0.45), camarinic acid (0.42), dihydrorehmannic acid (0.67), icterogenin (0.54), lantadene C (0.59), lantanillic acid (0.44), lantanolic acid (0.6), lantic acid (0.61), lantoic acid (0.49), pomolic acid (1), pomonic acid (0.82), Ursoxy acid (0.58) |
| PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | 3,22-Dihydroxy-12-oleanen-28-oic acid; (3β,22β)-form, 3-O-(3-methyl-2-butenoyl) (0.51), 3,24-dihydroxy-12-oleanen-28-oic acid; 3α;-form, 3-Ketone, 24-aldehyde (0.53), 3,24-dihydroxy-12-ursen-28-oic acid; 3β-form, 3-ketone (0.45), dihydrorehmannic acid (0.54), lantadene C (0.42), lantanolic acid (0.54), pomolic acid (0.54) |
| RELA | Transcription factor p65 | Ferulic acid (0.5), isoferulic acid (0.54) |
| RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | Narcissin (0.62), rhamnocitrin-O-glucoside (0.72) |
| SYK | Tyrosine-protein kinase SYK | Myricetin (1) |
| TLR2 | Toll-like receptor 2 | Arachidic acid (1), behenic acid (1), linoleic acid methyl ester (0.46), linolenic acid (0.48) |
| VEGFA | Vascular endothelial growth factor a | Afzelechin (1) |