Table 3.
KEGG pathway analysis of potential target genes functions.
| Pathway ID | Pathway name | Gene count | False discovery rate (P-value) | Matching proteins in the network |
|---|---|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | 17 | 6.54E−11 | IL2, FLT3, KIT, INSR, MET, PIK3CG, LPAR1, SYK, BCL2, RELA, CREB1, LPAR3, LPAR4, PRKCA, LPAR2, PGF, VEGFA |
| hsa04010 | MAPK signaling pathway | 16 | 1.59E−11 | MAPK14, FLT3, FGF2, KIT, BRAF, INSR, FOS, MET, MAPT, JUN, RPS6KA3, RELA, PLA2G4B, PRKCA, PGF, VEGFA |
| hsa04015 | Rap1 signaling pathway | 12 | 9.69E−12 | MAPK14, KIT, BRAF, INSR, MET, LPAR1, LPAR3, LPAR4, PRKCA, LPAR2, PGF, VEGFA |
| hsa04014 | Ras signaling pathway | 11 | 1.63E−09 | FLT3, PLA2G2C, KIT, INSR, MET, PLA2G5, RELA, PLA2G4B, PRKCA, PGF, VEGFA |
| hsa04072 | Phospholipase D signaling pathway | 10 | 6.41E−08 | KIT, INSR, PIK3CG, LPAR1, SYK, LPAR3, PLA2G4B, LPAR4, PRKCA, LPAR2 |
| hsa05418 | Fluid shear stress and atherosclerosis | 7 | 4.56E−10 | MAPK14, FOS, JUN, MMP9, BCL2, RELA, VEGFA |
| hsa04024 | cAMP signaling pathway | 7 | 2.50E−05 | PTGER2, BRAF, FOS, JUN, RELA, PPARA, CREB1 |
| hsa04510 | Focal adhesion | 7 | 0.00011 | BRAF, MET, JUN, BCL2, PRKCA, PGF, VEGFA |
| hsa04662 | B cell receptor signaling pathway | 6 | 3.60E−08 | CD81, FOS, JUN, SYK, RELA, PTPN6 |
| hsa04668 | TNF signaling pathway | 6 | 0.00000111 | MAPK14, FOS, JUN, MMP9, RELA, CREB1 |
| hsa04660 | T cell receptor signaling pathway | 6 | 3.63E−06 | IL2, MAPK14, FOS, JUN, RELA, PTPN6 |
| hsa04722 | Neurotrophin signaling pathway | 6 | 6.06E−05 | MAPK14, BRAF, JUN, RPS6KA3, BCL2, RELA |
| hsa04060 | Cytokine-cytokine receptor interaction | 6 | 0.0085 | IL2, FLT3, KIT, MET, CXCL12, VEGFA |
| hsa04064 | NF-kappa B signaling pathway | 5 | 3.35E−07 | SYK, CXCL12, BCL2, RELA |
| hsa04066 | HIF-1 signaling pathway | 5 | 3.44E−06 | INSR, BCL2, RELA, PRKCA, VEGFA |
| hsa04620 | Toll-like receptor signaling pathway | 5 | 4.45E−06 | MAPK14, TLR2, FOS, JUN, RELA |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 5 | 4.51E−06 | BRAF, MET, BCL2, PRKCA, VEGFA |
| hsa04657 | IL-17 signaling pathway | 5 | 1.40E−05 | MAPK14, FOS, JUN, MMP9, RELA |
| hsa05323 | Rheumatoid arthritis | 5 | 4.85E−05 | TLR2, FOS, JUN, CXCL12, VEGFA |
| hsa04659 | Th17 cell differentiation | 5 | 0.00013 | IL2, MAPK14, FOS, JUN, RELA |
| hsa04658 | Th1 and Th2 cell differentiation | 5 | 0.00032 | IL2, MAPK14, FOS, JUN, RELA |
| hsa04071 | Sphingolipid signaling pathway | 4 | 1.33E−13 | MAPK14, BCL2, RELA, PRKCA |
| hsa04670 | Leukocyte transendothelial migration | 4 | 1.46E−06 | MAPK14, MMP9, CXCL12, PRKCA |
| hsa04611 | Platelet activation | 4 | 0.00000329 | MAPK14, PIK3CG, SYK, PLA2G4B |
| hsa04210 | Apoptosis | 4 | 6.21E−06 | FOS, JUN, BCL2, RELA |
| hsa04750 | Inflammatory mediator regulation of TRP channels | 4 | 0.000014 | MAPK14, PTGER2, PLA2G4B, PRKCA |
| hsa04370 | VEGF signaling pathway | 4 | 0.0000473 | MAPK14, PLA2G4B, PRKCA, VEGFA |
| hsa05321 | Inflammatory bowel disease (IBD) | 4 | 6.06E−05 | IL2, TLR2, JUN, RELA |
| hsa04621 | NOD-like receptor signaling pathway | 4 | 0.00013 | MAPK14, JUN, BCL2, RELA |
| hsa04150 | mTOR signaling pathway | 4 | 0.00026 | BRAF, INSR, RPS6KA3, PRKCA |
| hsa04520 | Adherens junction | 4 | 0.0037 | INSR, MET, PTPN1, PTPN6 |
| hsa00590 | Arachidonic acid metabolism | 3 | 8.61E−11 | PLA2G2C, CBR1, PLA2G5, PLA2G4B |
| hsa04062 | Chemokine signaling pathway | 3 | 6.06E−05 | BRAF, CXCL12, RELA |
| hsa04022 | cGMP-PKG signaling pathway | 3 | 0.00042 | INSR, PIK3CG, CREB1 |
| hsa04720 | Long-term potentiation | 3 | 0.00042 | BRAF, RPS6KA3, PRKCA |
| hsa04012 | ErbB signaling pathway | 3 | 0.0014 | BRAF, JUN, PRKCA |
| hsa04360 | Axon guidance | 3 | 0.0027 | MET, CXCL12, PRKCA |
| hsa00564 | Glycerophospholipid metabolism | 3 | 0.0117 | PLA2G2C, PLA2G5, PLA2G4B |
| hsa04068 | FoxO signaling pathway | 3 | 0.032 | MAPK14, BRAF, INSR |
| hsa04920 | Adipocytokine signaling pathway | 2 | 0.0033 | RELA, PPARA |
| hsa04218 | Cellular senescence | 2 | 0.0056 | MAPK14, RELA |
| hsa04622 | RIG-I-like receptor signaling pathway | 2 | 0.0185 | MAPK14, RELA |
| hsa04217 | Necroptosis | 2 | 0.0193 | BCL2, PLA2G4B |
| hsa05014 | Amyotrophic lateral sclerosis (ALS) | 2 | 0.036 | MAPK14, BCL2 |
| hsa04310 | Wnt signaling pathway | 2 | 0.0442 | JUN, PRKCA |
| hsa04922 | Glucagon signaling pathway | 2 | 0.0489 | PPARA, CREB1 |
| hsa04371 | Apelin signaling pathway | 1 | 0.0027 | PIK3CG |