Figure 1:

Predictive capabilities of MRS on aeroallergen sensitization. Four different models and criterions are displayed, assessing the cross-sectional and prospective impact of MRS as well as their (A) mean effect size per publication over all p-value thresholds, (B) performance and (C) explained variance for the different p-values thresholds (determining how many CpG sites were included in the MRS). All models are adjusted for sex, age, whether the blood was taken within the allergy season and cell type proportions. RR (A) were derived from Poisson regressions, whereas the other criterions (B&C) were calculated using logistic regression. Sample sizes for the four models were n = 234, n = 227, n = 234 and n = 167, respectively.