Table 1:
Sample information and variable distribution in the final analysis sets at six and ten years of age in the LISA birth cohort.
| Analysis sample (N = 240) |
||
|---|---|---|
| DNAm measured at 6 years (N = 234) |
DNAm measured at 10 years (N = 227) |
|
| Male sex, % (n) [n missing] | 57.69% (135) [0] | 57.71% (131) [0] |
| Age at DNA methylation measurement [years], mean (sd) | 6.072 (0.15) | 10.155 (0.14) |
| High parental education1, % (n) [n missing] | 79.49% (186) [2] | 79.74% (181) [2] |
| Aeroallergen sensitization2, % (n) [n missing] | ||
| At 6 years | 31.62% (74) [0] | 29.96% (68) [0] |
| At 10 years | 44.87% (105) [0] | 44.49% (101) [0] |
| At 15 years | 37.18% (87) [63] | 37.00% (84) [60] |
| Allergic symptoms in last 12 months, % (n) [n missing] | ||
| Rhino-conjunctivitis | 8.55% (20) [1] | 14.98% (34) [4] |
| Wheezing | 10.68% (25) [2] | 7.93% (18) [2] |
| Blood taken in allergy season (Mar - Aug), % (n) [n missing] | ||
| At 6 years | 67.52% (158) [0] | 66.96% (152) [0] |
| At 10 years | 52.99% (124) [0] | 51.10% (116) [0] |
| At 15 years | 41.45% (97) [55] | 39.65% (90) [52] |
| Polygenic Risk Scores3, mean (sd) | ||
| Any allergic disease | 0.187 (0.95) | 0.187 (0.93) |
| Asthma | 0.147 (1.04) | 0.155 (1.05) |
| Dermatitis | 0.002 (0.99) | −0.014 (0.99) |
| Rhinitis | 0.023 (0.97) | 0.052 (0.95) |
| Total IgE | 0.083 (0.97) | 0.084 (0.97) |
| Family history of allergic diseases, % (n) [n missing] | ||
| No parent | 29.06% (68) [24] | 28.19% (64) [24] |
| One parent | 42.74% (100) [24] | 43.17% (98) [24] |
| Both parents | 17.95% (42) [24] | 18.06% (41) [24] |
| Other known risk factors for allergy, % (n) [n missing] | ||
| Smoking during pregnancy | 7.26% (17) [7] | 7.05% (16) [6] |
| Breastfeeding in first 4 months | 83.33% (195) [1] | 83.70% (190) [1] |
| Older siblings | 49.57% (116) [0] | 48.90% (111) [0] |
| ETS4 in first 4 years | 25.64% (60) [3] | 25.11% (57) [3] |
| Bronchitis infection in first 3 years | 64.96% (152) [2] | 66.96% (152) [2] |
| Cat or dog in first 4 years | 19.66% (46) [8] | 19.82% (45) [9] |
1
defined as more than 10 years of education
2
defined by a specific IgE threshold of >0.35 kU/L (Radio-Allergo-Sorbent-Test (RAST) class 1)
3
z-scores
4
Environmental tobacco smoke exposure; If time point of measurement is not mentioned, data were obtained from questionnaire data filled out by the LISA parents at birth, 1, 2 or 4 years of age.