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. 2022 Sep 2;3:27. doi: 10.1186/s43556-022-00092-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — In vitro and in vivo sterility of C11orf94^−/− mice. a Litter size of crosses between C57BL/6 females (n ≥ 6) and C11orf94^−/−, C11orf94^±, C11orf94^+/+ males (n ≥ 6). Values indicate mean ± SEM. The numbers in brackets represent the number of mating pairs (**, p < 0.01). b Litter size of crosses between C57BL/6 male mice (n ≥ 6) and C11orf94^−/−, C11orf94^±, C11orf94^+/+ females (n ≥ 6). Values indicate mean ± SEM. The numbers in brackets represent the number of mating pairs. ns: no significance. c Total offspring per mouse over time for the three genotype male mice. d Sperm sterility with cumulus-intact oocytes by in vitro fertilization test. Sperm exact from the cauda epididymis of three genotype mice and cumulus-intact oocytes derive from wild type C57BL/6 female mice. Here is representative diagram of 2-cell in the fertilized oocyte development. e The ratio of pronucleus development to total oocytes. There was significant difference between C11orf94^−/− males and C11orf94^+/+ or C11orf94.^± males (***, p < 0.005)