Fig. 1.

Flowchart for DME management. *Rule out contraindications for anti-VEGF. **Rule out contraindications for dexamethasone implant. ***Poor response: failure to gain at least 5 letters of vision; failure to reduce CRT by 10%. ****Rule out contraindications for fluocinolone implant. BCVA best-corrected visual acuity, CRT central retinal thickness, dex, dexamethasone, DME diabetic macular edema, FFA fundus fluorescein angiography, IOP intraocular pressure, MI myocardial infarction, OCT optical coherence tomography, OCTA optical coherence tomography angiography, PRN pro re nata, VEGF vascular endothelial growth factor