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. 2022 Aug 19;13:983920. doi: 10.3389/fphar.2022.983920

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Copyright © 2022 Chen, Chen, Deng, Wei, Qian, Huang, Wu, Gao, Gong, Liao and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DEX reduced inflammatory factor protein expression and inhibited microglial activation in neonatal rats with HIBD. (A) Representative IF image (magnification ×1, scale bar: 1000 μm; magnification ×800, scale bar: 20 μm) showing the levels of microglial activation in the sham, HI and HI + DEX groups on D2. (B–C) Representative western blot image and quantitative analysis of the western blot (bar chart) illustrating the protein levels of crucial inflammatory factors, including TNF-α, IL-1β and IL-6, on D2. DEX, Dexmedetomidine; HIBD, Hypoxic-ischemic brain damage; IF, Immunofluorescence; HI, Hypoxic-ischemia; D2, 2 days after HIBD. Data are expressed as the mean ± SD (n = 5 per group). *p < 0.05 vs. the sham group; ^# p < 0.05 vs. the HI group.