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. 2022 Aug 19;13:963799. doi: 10.3389/fphys.2022.963799

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Copyright © 2022 Alvarez Villela, Dunworth, Kraft, Harlan, Natoli, Suliman and Moon.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study design. After a sea-level screening VO2peak test, subjects underwent a V̇O2peak test at altitude and were then randomized to HIIT + Air or HIIT + HBO₂. After six HIIT sessions, subjects underwent a final V̇O2peak test at altitude. Abbreviations: ATM, atmospheres; HBO₂, hyperbaric oxygen; HIIT, high-intensity interval training; PiO₂, pressure of inspired oxygen; VL, vastus lateralis; V̇O2, oxygen consumption.