TABLE 1.
WT | WT dapa | db/db | db/db dapa | |
---|---|---|---|---|
Steatosis | 0 | 0 | 1.225 ± 0.160*** | 0.175 ± 0.048### & |
Lobular inflammation | 0.125 ± 0.048 | 0.15 ± 0.065 | 0.400 ± 0.087* | 0.100 ± 0.058# |
Ballooning | 0 | 0.050 ± 0.050 | 2 | 1.250 ± 0.218# && |
NAS | 0.150 ± 0.050 | 0.200 ± 0.071 | 3.67 ± 0.236*** | 1.525 ± 0.197### &&& |
Values were mean ± SEM, n = 4. *p < 0.05, **p < 0.01, and ***p < 0.001 vs. wild-type mice (WT). # p < 0.05, ## p < 0.01, and ###p < 0.001 vs. db/db mice. & p < 0.05, && p < 0.01, and &&& p < 0.001 vs. dapagliflozin-treated wild-type mice. One-way ANOVA, Bonferroni’s multiple comparison test. Dapa = dapagliflozin.