TABLE 1.

Therapeutic potential and molecular mechanisms of salidroside in animal models with ischemic diseases.

Ischemic disease	Model	Pathway	References
Cerebral ischemia	MCAO mice	PI3K/Akt/mTOR	Chen et al. (2012b), Zhang et al. (2018)
	MCAO rats	TH/MAO; Nrf2	Han et al. (2015), Zhong et al. (2019)
Ischemic heart disease	MI/RI rats	TLR4/NF-κB; Apoptosis	Zhu et al. (2015b)
	MI rabbits	PI3K/Akt	Xu et al. (2013)
	Severe sleep apnea mice	Apoptosis	Lai et al. (2014)
	AMI rats	Apoptosis	Li et al. (2016)
	MI rats	PI3K/Akt/mTOR; Nox/NF-κB/AP1	Zhu et al. (2015a), Chen et al. (2017)
	MI mice	Fas/mitochondria-dependent apoptosis; PI3K/Akt/mTOR	Chen et al. (2019)
Liver ischemia	Hepatic I/R mice	MAPK; PI3K/Akt	Feng et al. (2017), Feng et al. (2018)
	NAFLD mice	TXNIP/NLRP3	Zheng et al. (2018)
Ischemic AKI	AKI septic rats	NF-κB; apoptosis	Fan et al. (2022)
	DN rats	PHD2/HIF-1	Xie et al. (2019)
	DKD rats	Apoptosis	Guo et al. (2018a)
Lower limb ischemia	HLI mice	PHD3/HIF-1α	Ariyanti et al. (2017), Zhang et al. (2017)