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. 2022 Aug 19;10:947376. doi: 10.3389/fcell.2022.947376

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Copyright © 2022 Beaven and Denholm.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypothetical mechanisms for distal patterning in the developing Malpighian tubules. (A′) The distal tubule domain is specified by an inductive signal emanating from the distal tubule end, or (A′′) an inhibitory signal from the proximal tubule end. (B) The distal tubule domain is pre-patterned in the primordium.