Table 4.

Combined incidence of anxiety and depression and breast cancer cohort to comparison cohort adjusted hazard ratio by age, occupation, income, urbanization, and Charlson comorbidity index score.

Variable	BC control			Breast cancer			Adjusted HR (95% CI)
	Event, n	PY	Rate	Event, n	PY	Rate
Overall	10,002	632,488	15.8	12,530	549,703	22.8	1.40 (1.37-1.44)***
Age, years
18-39	854	95,003	8.99	1,400	78,297	17.9	1.91 (1.75-2.07)***
40-49	3,438	234,562	14.7	4,348	19,962	21.8	1.44 (1.38-1.51)***
50-64	4,182	231,962	18.0	5,039	201,127	25.0	1.36 (1.30-1.41)***
65-74  75+	983 545	44,085 26,876	22.3 20.3	1,332 411	51,600 19,069	25.8 21.6	1.15 (1.06-1.25)*** 1.07 (0.94-1.22)
Occupation
Homemaker	2,862	164,289	17.4	3,480	145,502	23.9	1.34 (1.28-1.41)***
White collar	2,633	209,800	12.6	3,563	183,478	19.4	1.51 (1.43-1.58)***
Blue collar	3,370	190,807	17.7	4,147	164,392	25.4	1.40 (1.34-1.46)***
Other	1,137	67,592	16.8	1,340	57,232	23.4	1.35 (1.25-1.46)***
Income
≤20,000	4,844	270,388	17.9	5,472	230,279	23.8	1.29 (1.24-1.34)***
20,001-39,999	3,409	232,941	14.6	4,639	203,872	22.7	1.51 (1.45-1.58)***
40,000+	1,749	129,159	13.5	2,419	11,553	20.9	1.51 (1.42-1.60)***
Urbanization
Urban	6,008	382,364	15.7	7,462	334,402	22.3	1.39 (1.34-1.43)***
Suburban	3,119	197,532	15.8	3,859	167,820	23.0	1.41 (1.35-1.48)***
Rural	875	52,592	16.6	1,209	47,481	25.5	1.48 (1.36-1.62)***
CCI score
0	9,380	602,452	15.6	11,644	510,899	22.8	1.42 (1.39-1.46)***
1+	622	30,036	20.7	886	38,804	22.8	1.12 (1.01-1.24)*

PY, person-years; Rate, per 1,000 person-years; CCI, Charlson comorbidity index.

Adjusted for matched pair. *p < 0.05, ***p < 0.001.