TABLE 2.

Pharmacological activities of Actinidia eriantha Benth.

Pharmacological activity	Tested substance	Model	Tested living system/organ/cell	Result	Dose range	Time period of application	References
Immunoregulatory activity	Aeps	Raw264.7cells	Cells	Induced the activation of macrophages via lncrnas/nf-κb networks	50 μg/ml	4 h	Chen et al. (2019a)
	AEPS	RAW264.7cells	Cells	Induced macrophage activation through regulating mirnas expression	50 μg/ml	24 h	Chen et al. (2019b)
	AEPS	Mice	Supernatant and the elleted cells	Induced the expression of large numbers of cytokines and chemokines	50 μg	3, 6 h	Du et al. (2020)
	AEPS	RAW264.7 cells	Cells	Enhanced the pinocytic and phagocytic activity, promote the expression of accessory and costimulatory molecules	0–200 μg/ml	24 h	Sun et al. (2015)
	AEPS	Icrmice	Sera and splenocyte	Increased both cellular and humoral immune responses and elicited a balanced Th1/Th2 response	25,50, 100 μg	2 weeks	Sun et al. (2009)
	Phenoplic extracts	Splenocyte	Cell	Induced the proliferation and reduced IFN-γ production	62.5–1,000 μg/ml	48 h	Kim et al. (2018)
Antitumor activity	Eel, ees	Huvecs	Cells	Decreased the Cell viability	100 μg/ml	24 h	Wu et al. (2017)
	EER	SGC7901 cells, CNE2 cells and huvecs	Cells	Inhibited the cells’ growth	100 μg/ml	24 h	Wu et al. (2017)
	PE-EER, BA-EER, WE-EER	Huvecs	Cells	Inhibited the cells’ growth	100 μg/ml	24 h	Wu et al. (2017)
	EA-EER	CNE2 cells	Cells	Inhibited the cells’ growth	100 μg/ml	24 h	Wu et al. (2017)
	EA-EER	SGC7901 cells, huvecs	Cells	Inhibited the cells’ growth in a time and dose-dependent manner	0–100 μg/ml	24, 48, 72 h	Wu et al. (2017)
	EA-EER	SGC7901 cells	Cells	Decreased the Number of cells and ncreasing degree of apoptosis with some obvious apoptotic morphological alterations	0, 50, 75 and 100 μg/ml	24 h	Wu et al. (2017)
	EA-EER	Huvecs	Cells	Induced apoptosis	0, 40, 60, 80 μg/ml	24 h	Wu et al. (2017)
	EA-EER	Huvecs	Cells	Inhibit cell migration of huvecs in a dose-dependent manner	0, 30, 40, 60 μg/ml	24 h	Wu et al. (2017)
	EA-EER	Chick CAM model	Blood vessels	Was capable of restraining angiogenesis in vivo	1.0 mg/ml	72 h	Wu et al. (2017)
	AEPS and AEPA, AEPB, AEPC, AEPD	Tumor-bearing mice	Tumors	Inhibited the growth of tumor transplanted	2.5, 5.0, 10.0 mg/kg	10 days	Xu et al. (2009b)
	AEPS and AEPA, AEPB, AEPC, AEPD	S180-bearing mice	S180 sarcoma	Inhibited the growth of transplantable S180 sarcoma in mice and promoted splenocytes proliferation, natural killer cells activity, interleukin-2 production from splenocytes and serum tumor antigen-specific antibody levels in tumor-bearing	10 mg/kg	5 days	Xu et al. (2009a)
Anti-angiogenic activity	Ea-eer	Sgc7901 cells	Cells	Downregulated mrna expression of bcl-2 and up-regulated mrna expression of bcl-2 and the protein expression of caspase-3in sgc7901 cells, in a dose-dependent manner	0, 40, 60, 80 μg/ml	24 h	Wu et al. (2017)
	EA-EER	Huvecs	Cells	Reduced mrna expression of VEGF-A and VEGFR-2 in huvecs	0, 40, 60, 80 μg/ml	24 h	Wu et al. (2017)
Neuroprotective activity	Aqueous ethanol	Pc-12 cells	Cells	Protected neuron-like pc-12 cells from aβ1-42 -induced neurotoxicity	62.5, 250, and 1,000 μg/ml	24 h	Cho et al. (2021)
	Aqueous ethanol	ICR mice	Mice	Prevented cognitive impairment	50, 200, and 1,000 mg/kg	3 weeks	Cho et al. (2021)
	Aqueous ethanol	ICR mice	Brain tissue	Ameliorated Aβ1-42 -induced spatial cognitive learning and memory deficits and protected the antioxidant defense systems in brain tissue	50, 200, and 1,000 mg/kg	3 weeks	Cho et al. (2021)
Anti-inflammatory activity	Phenolic extracts	Macrophages	Cells	Inhibited the production of the pro-inflammatory cytokines	62.5–1,000 μg/ml	48 h	Kim et al. (2018)