Table 6.

Correlations between NAA/Cho, NAA/Cr, and Cho/Cr / Lac/Cr ratio (GM and WM) with ASQ, in univariate analysis.

Gray matter	NAA/Cho			NAA/Cr			Cho/Cr			Lac/Cr
	N	P	OR IC (95%)	N	P	OR IC (95%)	N	P	OR IC (95%)	N	P	OR IC (95%)
Communication	51	0.28	0.11 [0.002–6.12]	51	0.50	0.54 [0.090–3.26]	51	0.99	1.00 [0.341–2.96]	51	0.90	1.25 [0.03–50.59]
Gross motor	51	0.36	0.04 [0.000–33.35]	51	0.30	0.16 [0.006–4.96]	51	0.63	0.61 [0.080–4.699]	51	0.59	4.00 [.025–644.59]
Fine motor	50	0.75	0.38 [0.001–166.64]	50	0.07	0.02 [0.000–1.45]	51	0.12	0.08 [0.004–1.927]	51	0.91	1.37 [0.004–471.83]
Problem solving	51	0.99	0.97 [0.012–79.95]	53	0.12	0.11 [.007–1.82]	51	0.14	0.20 [0.026–1.675]	51	0.45	4.90 [0.07– 310.91]
Personal and social skills	51	0.18	0.02 [0.000–5.51]	51	0.59	0.52 [0.05–5.54]	51	0.88	1.10 [.285–4.29]	51	1.94	1.94 [0.023 164.92]
ASQ total		0.68	0.780 [0.231–2.629]		0.76	1.061 [0.720–1.562]		0.92	1.010 [0.825–1.236]
White matter
Communication	55	0.06	0.01 [0.000–1.254]	55	0.38	0.69 [0.303–1.59]	55	0.85	0.94 [0.52–1.71]	55	0.65	1.55 [0.22–10.65]
Gross motor	54	0.64	0.20 [0.000–185.768]	54	0.64	0.20 [0.000–185.76]	54	0.43	0.60 [0.16–2.16)	54	0.49	0.181[0.001–23.00]
Fine motor	55	0.66	0.22.[0.000–213.902]	55	0.66	0.22 [0.000–213.90]	55	0.73	1.16 [0.47–2.82]	55	0.03	14.98 [1.158–193.87]
Problem solving	55	0.81	047[0.001–231.977]	55	0.81	0.47 [0.001–231.97]	55	0.33	0.53 [0.14–1.91]	55	0.77	1.48 [0.09–22.90]
Personal and social skills	55	0.94	1.19 [0.007–198.078]	55	0.94	1.19 [0.007–198.07]		0.55	1.23 [0.63–2.45]	55	0.46	2.29 (0.25–20.93]
ASQ total		0.06	0.489 [0.231–1.037]		0.96	0.487 [0.854–1.080]	55	0.87	1.007 [0.925–1.096]

P, p–value; NAA, N Acetyl Aspartate; Cr, Creatine; Cho, Choline; Lac, Lactate.

OR, represents the correlation between the MRS (magnetic resonance spectroscopy) ratios and the pathological ASQ score.

ASQ, age and stage questionnaire; DEHSI, diffuse excessive high signal intensity.

Variables are expressed as means ± standard deviations; numbers in brackets are ranges.