Table 7.
Correlations between NAA/Cho. NAA/Cr and Cho/Cr / Lac/Cr ratio (GM and WM) with ASQ, in multivariate analysis.
| Gray Matter | NAA/Cho | NAA/Cr | Cho/Cr | Lac/Cr | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | P | OR IC (95%) | N | P | OR IC (95%) | N | P | OR IC (95%) | N | P | OR IC (95%) | |
| Communication | 48 | 0.19 | 0.058 [0.001–4.38] | 48 | 0.33 | 0.37 [0.052–2.75] | 48 | 0.95 | 1.035[.336–3.18] | 48 | 0.43 | 5.04 [0.08–288.46] |
| Gross motor | 48 | 0.35 | 0.028 [0.000–52.02] | 48 | 0.48 | 0.25 [0.005–12.38] | 48 | 0.91 | 0.89 [.118–6.822] | 48 | 0.35 | 15.14 [0.048 −4,817.57] |
| Fine motor | ||||||||||||
| Problem solving | 48 | 0.95 | 0.87 [0.008–93.81] | 48 | 0.23 | 0.17 [.010–3.055] | 48 | 0.26 | 0.31 [0.039–2.46] | 48 | 0.10 | 90.72 [0.0365 −22,570.95] |
| Personal and social skills | 48 | 0.10 | 0.006 [0.000–2.74] | 48 | 0.28 | 0.18 [0.008–4.07] | 48 | 0.97 | 1.02 [.225–4.70] | 48 | 0.54 | 4.23 [0.04– 450.04] |
| ASQ total | 47 | 0.64 | 0.042[0.001– 35,112.27] | 50 | 0.26 | 0.36.[0.061–2.4] | 48 | 0.408 | 0.61 [0.18 −1.94] | 50 | 0.40 | 0.61 [0.18–1.94] |
| White matter | ||||||||||||
| Communication | 51 | 0.04 | 0.003[0.000–0.95] | 48 | 0.43 | 0.67 [0.248–1.828] | 48 | 0.77 | 0.90 [0.468– 1.76] | 48 | 0.512 | 1.97.[0.26– 14.92] |
| Gross motor | 51 | 0.70 | 0.18 [0.000–1,031.22] | 48 | 0.70 | 0.18 [0.000 1,031.22] |
48 | 0.63 | 0.72 [0.19– 2.68] | 48 | 0.61 | 0.29.[0.26 14.92] |
| Fine motor | 51 | 0.76 | 0.27 [0.00–1,390.69] | 0.85 | 1.11 [0.343– 3.64] |
0.65 | 1.23 [0.487– 3.141] | 0.02 | 39.35 [0.003 33.57] |
|||
| Problem solving | 51 | 0.72 | 4.31 [0.001–14,163.8] | 48 | 0.43 | 0.48 [0.07– 3.03] |
48 | 0.72 | 4.31 [0.001 14,163.87] | 48 | 0.51 | 2.53 [1.777– 871.30] |
| Personal and social skills | 51 | 0.61 | 5.29 [0.008–3,660.75] | 48 | 0.51 | 1.40 [0.50– 3.93] |
48 | 0.61 | 5.29 [0.008– 3,660.75] | 48 | 0.25 | 3.79 [3.7 37.22] |
| ASQ total | 50 | 0.049 | 0.005 [0.000– 1.19] | 50 | 0.23 | 0.575[0.23– 1.42] |
50 | 0.44 | 0.78 [0.41 1.46] | 50 | 0.36 | 2.567[0.03 19.78] |
NAA, N Acetyl Aspartate; Cr, Creatine; Cho, Choline; Lac, Lactate.
Multivariate analysis, a forced adjustment was performed.
GA and variables related to at least one of the ratios (in Tables 5A,B at threshold p <0.10) (PN and WM volume reduction for GM) and DESHI and lateral ventricular dilation for WM.
OR, represents the correlation between the MRS (magnetic resonance spectroscopy) ratios and the pathological ASQ score.