Table 2.
Demographic and sonographic characteristics of PTMC patients by BRAF mutation status in the training cohort (n = 232).
| Variables | BRAF (−) (n = 64) | BRAF (+) (n = 168) | P-value |
|---|---|---|---|
| Gender | 0.149 | ||
| Female | 53 (82.8%) | 122 (72.6%) | |
| Male | 11 (17.2%) | 46 (27.4%) | |
| Multifocality | 0.477 | ||
| Negative | 54 (84.4%) | 133 (79.2%) | |
| Positive | 10 (15.6%) | 35 (20.8%) | |
| Primary site | 0.864 | ||
| Right lobe | 32 (50%) | 87 (51.8%) | |
| Left lobe | 29 (45.3%) | 70 (41.7%) | |
| Isthmus | 3 (4.7%) | 11 (6.5%) | |
| Tumor location | 0.729 | ||
| Intrathyroidal | 40 (62.5%) | 99 (58.9%) | |
| Subcapsular thyroid | 24 (37.5%) | 69 (41.1%) | |
| Tumor size (mm) | 0.549 | ||
| ≤5 | 14 (21.9%) | 45 (26.8%) | |
| 5–10 | 50 (78.1%) | 123 (73.2%) | |
| Composition | 0.046* | ||
| Mixed cystic and solid | 8 (12.5%) | 8 (4.8%) | |
| Solid | 56 (87.5%) | 160 (95.2%) | |
| Homogeneity | 0.499 | ||
| Homogeneous | 21 (32.8%) | 65 (38.7%) | |
| Heterogeneous | 43 (67.2%) | 103 (61.3%) | |
| Aspect ratio ≥1 | 0.018* | ||
| Absent | 26 (40.6%) | 40 (23.8%) | |
| Present | 38 (59.4%) | 128 (76.2%) | |
| Calcification | 0.955 | ||
| Absent | 28 (43.8%) | 76 (45.2%) | |
| Present | 36 (56.2%) | 92 (54.8%) | |
| Close to the trachea cartilage | 0.696 | ||
| Absent | 55 (85.9%) | 139 (82.7%) | |
| Present | 9 (14.1%) | 29 (17.3%) | |
| Vascular type | 0.087 | ||
| Type 0 | 12 (18.8%) | 22 (13.1%) | |
| Type 1 | 9 (14.1%) | 45 (26.8%) | |
| Type 2 | 14 (21.9%) | 44 (26.2%) | |
| Type 3 | 8 (12.5%) | 24 (14.3%) | |
| Type 4 | 21 (32.8%) | 33 (19.6%) | |
| Age, median (IQR) | 39 (32.75, 46.25) | 39 (34.75, 47) | 0.585 |
| Rad-score, median (IQR) | 0.76 (0.51, 1.01) | 1.04 (0.67, 1.39) | <0.001 |
PTMC, papillary thyroid microcarcinoma; Rad-score, radiomics score; IQR, interquartile range. *p < 0.05.