Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
NETs in cancer therapy resistance. After chemotherapy and radiotherapy, DAMPs (HMGB1) or other signals from cancer cells induce NET generation, contributing to therapy resistance. Neutrophils in tumor microenvironments expelled NETs, which protected tumor cells from cytotoxicity through CD8+ T cells and NK In addition, NETs decorated with PD-L1 neutralized the function of CD8+ T cells, resulting in checkpoint blockade in immunotherapy.
