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. 2022 Aug 19;10:957292. doi: 10.3389/fcell.2022.957292

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Copyright © 2022 Zhong, Liu, Chen, Sun, Hu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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eSCAN workflow. (A) eSCAN takes genotype and phenotype as well as a list of predefined enhancer (En1-En6 in the illustration) regions as input. (B) Aggregation-based association tests are performed in the enhancer-screening step to identify significant enhancer(s). In this illustration, En2 (green), En3 (yellow), and En6 (turquoise) are deemed significant. (C) eSCAN performs dynamic sliding window scanning within the significant enhancer region(s) to further narrow down the associated region. For example, En2* is the associated sub-region within En2 after narrowing down via dynamic scanning. Similar for En3* and En6*.