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. 2022 Jun 3;20(9):1365–1378. doi: 10.1158/1541-7786.MCR-21-1018

Figure 2.

Figure 2. The role of PPM1D in DNA repair. The red proteins are known PPM1D targets. The red inhibitory symbol denotes the inactivation of that protein upon PPM1D dephosphorylation. The green arrow represents activation of the protein upon dephosphorylation. A, PPM1D inhibits key players involved in DSB repair resulting in decreased NHEJ and increased HR. B, PPM1D inhibits several BER and NER proteins leading to decreased single-stranded break repair.

The role of PPM1D in DNA repair. The red proteins are known PPM1D targets. The red inhibitory symbol denotes the inactivation of that protein upon PPM1D dephosphorylation. The green arrow represents activation of the protein upon dephosphorylation. A, PPM1D inhibits key players involved in DSB repair resulting in decreased NHEJ and increased HR. B, PPM1D inhibits several BER and NER proteins leading to decreased single-stranded break repair.