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. 2022 Jun 3;20(9):1365–1378. doi: 10.1158/1541-7786.MCR-21-1018

Figure 3.

Figure 3. PPM1D-mediated suppression of cell-cycle arrest and apoptosis. A, PPM1D inhibits key cell-cycle regulators including p53, CHK, CHK2, p21, p27, and p38 leading to loss of cell-cycle arrest. B, PPM1D inhibits p53 leading to loss of proapoptotic factors resulting in suppression of apoptosis.

PPM1D-mediated suppression of cell-cycle arrest and apoptosis. A, PPM1D inhibits key cell-cycle regulators including p53, CHK, CHK2, p21, p27, and p38 leading to loss of cell-cycle arrest. B, PPM1D inhibits p53 leading to loss of proapoptotic factors resulting in suppression of apoptosis.