Table 1.
List of cell lines with PPM1D truncating mutations, amplifications, and copy-number gains curated from the Cell Model Passports database.
| Cell line | Cancer type | Nucleotide change | Amino acid change | Classification | TP53 status |
|---|---|---|---|---|---|
| SUP-T1 | TALL | c.1528_1529insA | p.N512fs*16 | Frameshift | 1 |
| MN-60 | BALL | p.N512fs*2 | c.1529delA | Frameshift | 0 |
| HCC1569 | BRCA | c.1344delT | p.L450fs*1 | Frameshift | 1 |
| PA-1 | OV | c.1370delC | p.A457fs*8 | Frameshift | 0 |
| PA-1 | OV | p.A457fs*8 | c.1370delC | Frameshift | 0 |
| U2OS | OS | c.1372C>T | p.R458* | Nonsense | 0 |
| BB58-HNC | HNC | p.N477fs*6 | c.1427delA | Frameshift | 0 |
| CCK-81 | CRC | p.N512fs*2 | c.1529delA | Frameshift | 1 |
| CL-34 | CRC | p.R572* | c.1714C>T | Nonsense | 1 |
| CW-2 | CRC | p.K336fs*3 | c.1003delA | Frameshift | 0 |
| HCM-SANG-520-C18 | CRC | p.N512fs*2 | c.1529delA | Frameshift | 1 |
| HCT-116 | CRC | c.1344delT | p.L450fs*1 | Frameshift | 0 |
| SNU-175 | CRC | p.N512fs*16 | c.1528_1529insA | Frameshift | 0 |
| HEC-108 | EC | p.L546fs*1 | c.1632delC | Frameshift | 1 |
| HEC-6 | EC | p.N512fs*16 | c.1528_1529insA | Frameshift | 1 |
| NCI-H3122 | NSCLC | p.N512fs*16 | c.1528_1529insA | Frameshift | 1 |
| Cell line | Cancer type | Copy number | Cell line | Cancer type | Copy number |
|---|---|---|---|---|---|
| ZR-75-30 | BRCA | 40 | NCI-H650 | NSCLC | 5 |
| MCF7 | BRCA | 30 | LN-229 | GBM | 5 |
| HCC2218 | BRCA | 23 | NCI-H2081 | SCLC | 5 |
| BT-474 | BRCA | 23 | KATOIII | GC | 5 |
| MDA-MB-361 | BRCA | 9 | CFPAC-1 | PC | 5 |
| SK-MEL-5 | MEL | 7 | NCI-H64 | SCLC | 5 |
| HCC1428 | BRCA | 7 | NCI-H740 | SCLC | 5 |
| UACC-893 | BRCA | 7 | SK-MEL-3 | MEL | 5 |
| NCI-H508 | CRC | 7 | DAN-G | PC | 5 |
| CAKI-1 | RCC | 6 | SK-MES-1 | SqCLC | 5 |
| NCI-H28 | MS | 6 | SW780 | BC | 5 |
| U-2-OS | OS | 6 | SK-N-DZ | NB | 5 |
| NCI-H1993 | NSCLC | 6 | NCI-H2009 | NSCLC | 4 |
| PANC-02-03 | PaC | 6 | MDA-MB-453 | BRCA | 4 |
| SK-MEL-1 | MEL | 6 | MHH-ES-1 | EW | 3 |
| PC-3 | PrC | 5 | NCI-H2405 | NSCLC | 3 |
| MDA-MB-330 | BRCA | 5 | MOLT-4 | TALL | 3 |
Abbreviations: BALL, B-cell acute myeloid leukemia; BC, bladder cancer; BRCA, breast cancer; CRC, colorectal; EC, endometrial carcinoma; GBM, glioblastoma; GC, gastric cancer; MEL, melanoma; MS, mesothelioma; NB, neuroblastoma; OS, osteosarcoma; OV, ovarian carcinoma; PaC, pancreatic cancer; PrC, prostate cancer; RCC, renal cell carcinoma; SCLC, small cell lung cancer; TALL, T-cell acute lymphoblastic leukemia.