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. 2022 Jul 6;12(9):2098–2119. doi: 10.1158/2159-8290.CD-21-1508

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 7. Endogenous TCR tracking as a broadly applicable method for CAR T cells. Schematic overview of the experimental approach and analytical pipeline for (i) identifying signatures associated with precursors of potent cytotoxic effectors in CAR GMP products, (ii) evaluating effector potential of CAR GMP products, and (iii) enriching CAR GMP products to maximize therapeutic potential. — Endogenous TCR tracking as a broadly applicable method for CAR T cells. Schematic overview of the experimental approach and analytic pipeline for (i) identifying signatures associated with precursors of potent cytotoxic effectors in CAR GMP products, (ii) evaluating effector potential of CAR GMP products, and (iii) enriching CAR GMP products to maximize therapeutic potential.