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SND1-BRAF transcript fusion in metastatic lung adenocarcinoma. (A) The primary structure of BRAF and its functional domains. (B) BRAF-RNF150 and SND1-BRAF fusions. RBD, ras-binding domain; CRD, cysteine-rich domain; PL, phosphate-binding loop; CL, catalytic loop; AL, activation loop; SND, staphylococcal nuclease domain; Ex, exon.
