Table 1.
Candidate of vaccines and antiviral drugs for prevention and treatment of human poxvirus.
| Categories | Names | Features | Anti-poxvirus | Reference |
|---|---|---|---|---|
| Vaccines | ACAM 2000 | Second-generation vaccine | Smallpox virus, MPXV | Brown and Leggat (2016) |
| IMVAMUNE | Third-generation vaccine | Smallpox virus, MPXV | Petersen et al. (2019a) | |
| Antiviral drugs | Tecovirimat (ST-246) | Small molecule virus inhibitor | Smallpox virus, MPXV, and cowpox virus. |
Yang et al. (2005), Thakur et al. (2022) |
| Cidofovir Brincidofovir 289 derivative (CMX001) |
Viral DNA polymerase inhibitors | MPXV |
Magee et al. (2008) Magee et al. (2005) Delaune and Iseni (2020) |
|
| Nioch-14 | Nucleoside analogues inhibitor | MPXV and vaccinia virus | Delaune and Iseni (2020) | |
| Ribavirin, Tiazofurin | Inosine monophosphate dehydrogenase inhibitors | All of poxviruses | Baker et al. (2003) | |
| C-CA3-ADO, C3-NPC A | S-adenosylhomocysteine hydrolase inhibitors | All of poxviruses | Baker et al. (2003) | |
| HPMA, Adenosine N1 oxide (ANO) | DNA polymerase inhibitors | All of poxviruses | Baker et al. (2003) | |