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. 2022 Aug 19;13:872421. doi: 10.3389/fphys.2022.872421

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Copyright © 2022 Banaras, Paracha, Nisar, Arif, Ahmad, Tariq Saeed, Mustansar, Shuja and Paracha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Paramater Scanning of TNF-α mediated Sphingolipid Signaling Pathway model interactions with known kinetic parameters from the literature to determine their tolerable range of variations and to study their effect on neuronal survival and death- (A) Paramater scanning for interaction 1 (Eq. 8) representing TNFR_TNFα formation. (B) Paramater scanning for interaction 2 (Eq. 9) representing recruitment of RAIDD. (C) Paramater scanning for interaction 8 (Eq. 10) representing formation of TNF_TRADD. (D) Paramater scanning for interaction 7 (Eq. 11) representing recruitment of FADD. (E) Paramater scanning for interaction 9 (Eq. 12) representing NFκB activation. (F) Paramater scanning for interaction 12 (Eq. 13) representing TRADD_TRAF2 comlex formation. (G) Paramater scanning for interaction 15 (Eq. 14) representing TNFR_FAN complex formation.(H) Paramater scanning for interaction 31 (Eq. 15) representing activation of S1PR. (I) Paramater scanning for interaction 38 (Eq. 16) representing recruitment of AKT.