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. 2022 Aug 19;13:872421. doi: 10.3389/fphys.2022.872421

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Copyright © 2022 Banaras, Paracha, Nisar, Arif, Ahmad, Tariq Saeed, Mustansar, Shuja and Paracha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Paramater scanning of Interactions having huge impact on the Neuronal Survival and Apoptosis- (A) Paramater scanning of Interaction 27 (Eq. 17) representing Cathepsin D activation. (B) Paramater scanning for Interaction 49 (Eq. 18) representing RIP recruitment. (C) Paramater scanning for Interaction 51 (Eq. 19) representing ERK-mediated Cell Death. The increasing parameter value of the interactions representing Cathepsin D activation and ERK-mediated Cell Death over the range of 0–0.2 enhances neuronal apoptosis and decreases neuronal survival. However, the increasing parameter value of the interactions representing recruitment of RIP only enhances neuronal apoptosis without impacting neuronal survival.