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. 2022 Aug 19;9:907832. doi: 10.3389/fmolb.2022.907832

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Copyright © 2022 Zhang, Li, Cui, Wu, Jiao, Yu, Gu, Chen, Zhang and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysregulated cochlear genes in mouse models due to noise exposure and their functional enrichment. (A) Gene numbers upregulated uniquely or consistently in the two kinds of mice due to noise exposure. (B) Gene numbers downregulated uniquely or consistently in the two kinds of mice due to noise exposure. (C) Pathways significantly associated with common upregulated genes in the susceptible B6 and resistant 129X mice due to noise exposure. (D,E) Pathways significantly associated with uniquely upregulated genes due to noise exposure in the susceptible B6 mice and resistant 129X mice, respectively. (F,G) Pathways significantly associated with uniquely downregulated genes due to noise exposure in the susceptible B6 mice and resistant 129X mice, respectively.