Table 1.
Baseline characteristics, suicide rates, and standardized mortality ratios (SMR) among pancreatic cancer patients (2000-2018).
| Characteristics | Total (%) | Suicides (%) | Person-years | Suicides per 100,000 Person-years | P | SMR | 95% CI |
|---|---|---|---|---|---|---|---|
| Total | 199,604 (100.0) | 180 (100.0) | 204,437.58 | 88.05 | 6.43 | 5.49 - 7.37 | |
| Year of diagnosis | 0.059$ | ||||||
| 2000-2005 | 51,047 (25.5) | 49 (27.2) | 55,323.79 | 88.57 | 7.03 | 5.16 - 9.26 | |
| 2006-2012 | 73,102 (36.6) | 56 (31.1) | 86,121.00 | 65.02 | 4.75 | 3.50 - 5.99 | |
| 2013-2018 | 75,455 (37.8) | 75 (41.6) | 62,992.79 | 119.06 | 7.73 | 5.98 - 9.48 | |
| Age groups | < 0.001$ | ||||||
| ≤ 53 | 20,966 (10.5) | 19 (10.6) | 41,090.71 | 46.24 | 2.36 | 1.43 - 3.68 | |
| 54-67 | 61,894 (31.0) | 59 (32.8) | 76,619.67 | 77.00 | 4.40 | 3.28 - 5.52 | |
| 68+ | 116,744 (58.4) | 102 (56.7) | 86,727.21 | 117.61 | 7.49 | 6.04 - 8.94 | |
| Sex | < 0.001 | ||||||
| Female | 98,690 (49.4) | 15 (8.3) | 101,974.21 | 14.71 | 2.37 | 1.33 - 3.94 | |
| Male | 100,914 (50.5) | 165 (91.6) | 102,463.38 | 161.03 | 7.06 | 5.98 - 8.13 | |
| Race | 0.001# | ||||||
| White | 160,190 (80.2) | 163 (90.5) | 164,759.79 | 98.93 | 5.47 | 4.63 - 6.31 | |
| Black | 23,959 (12.0) | 6 (3.3) | 22,743.33 | 26.38 | 3.61 | 1.29 - 7.71 | |
| Other | 15,455 (7.7) | 11 (6.1) | 16,934.46 | 64.96 | 9.69 | 4.91 - 17.91 | |
| Marital status | 0.200 | ||||||
| Married | 106,150 (53.1) | 96 (53.3) | 124,000.17 | 77.42 | 5.65 | 4.52 - 6.78 | |
| Unmarried | 25,531 (12.7) | 31 (17.2) | 26,736.50 | 115.95 | 8.46 | 5.68 - 11.89 | |
| DSW | 59,516 (29.8) | 44 (24.4) | 44,565.38 | 98.73 | 7.21 | 5.25 - 9.67 | |
| Unknown | 8,407 (4.2) | 9 (5.0) | 9,135.54 | 98.52 | 7.19 | 3.08 - 13.15 | |
| Stage | < 0.001$ | ||||||
| Localized | 21,505 (10.7) | 27 (15.0) | 45,751.88 | 59.01 | 4.31 | 2.83 - 6.22 | |
| Regional | 57,185 (28.6) | 50 (27.7) | 85,319.67 | 58.60 | 4.28 | 3.16 - 5.63 | |
| Distant | 102,280 (51.2) | 89 (49.4) | 58,263.21 | 152.76 | 11.15 | 8.81 - 13.44 | |
| Unknown/unstaged | 18,634 (9.3) | 14 (7.7) | 15,102.83 | 92.70 | 6.77 | 3.67 - 11.19 | |
| Grade | 0.895# | ||||||
| Grade I/II | 36,633 (18.3) | 44 (24.4) | 74,928.00 | 58.72 | 4.29 | 3.11 - 5.73 | |
| Grade III/IV | 26,472 (13.2) | 15 (8.3) | 26,573.46 | 56.45 | 4.12 | 2.33 - 6.89 | |
| Unknown | 136,499 (68.3) | 121 (67.2) | 102,936.13 | 117.55 | 8.58 | 7.05 - 10.11 | |
| Primary site | 0.380 | ||||||
| Head | 95,063 (47.6) | 89 (49.4) | 104,953.88 | 84.80 | 6.19 | 4.90 - 7.46 | |
| body or tails | 49,421 (24.7) | 44 (24.4) | 54,700.96 | 80.44 | 5.87 | 4.27 - 7.87 | |
| Others | 55,120 (27.6) | 47 (26.1) | 44,782.75 | 104.95 | 7.66 | 5.66 - 10.25 | |
| Histological type | < 0.001# | ||||||
| PDAC | 134,100 (67.1) | 124 (68.9) | 116,946.29 | 106.03 | 7.75 | 6.38 - 9.10 | |
| pNET | 11,538 (5.7) | 18 (10.0) | 41,358.83 | 43.52 | 3.16 | 1.89 - 5.01 | |
| PCN | 7,752 (3.8) | 9 (5.0) | 12,991.96 | 69.27 | 5.00 | 2.25 - 9.61 | |
| Unknown/Other types | 46,214 (23.1) | 29 (16.1) | 33,140.50 | 87.51 | 6.44 | 4.27 - 9.16 | |
| Radiotherapy | < 0.001 | ||||||
| No/Unknown | 172,819 (86.5) | 163 (90.5) | 160,203.13 | 101.75 | 7.43 | 6.27 - 8.55 | |
| Yes | 26,785 (13.4) | 17 (9.4) | 44,234.46 | 38.43 | 2.81 | 1.62 - 4.46 | |
| Chemotherapy | < 0.001 | ||||||
| No/Unknown | 112,980 (56.6) | 112 (62.2) | 96,603.58 | 115.94 | 8.46 | 6.91 - 10.06 | |
| Yes | 86,624 (43.3) | 68 (37.7) | 107,834.00 | 63.06 | 4.60 | 3.50 - 5.69 | |
| Surgery | < 0.001 | ||||||
| No/Unknown | 163,655 (81.9) | 143 (79.4) | 105,914.25 | 135.01 | 9.86 | 8.25 - 11.48 | |
| Yes | 35,949 (18.0) | 37 (20.5) | 98,523.33 | 37.55 | 2.74 | 1.93 - 3.78 | |
| Months elapsed from diagnosis | < 0.001$ | ||||||
| ≤ 2 | 76,951 (38.5) | 82 (45.5) | 6,607.42 | 1241.03 | 90.59 | 71.39 - 110.83 | |
| 3-12 | 73,512 (36.8) | 57 (31.6) | 39,355.17 | 144.83 | 10.57 | 7.82 - 13.30 | |
| 13+ | 49,141 (24.6) | 41 (22.7) | 158,475.00 | 25.87 | 1.89 | 1.35 - 2.56 |
SMR, Standardized mortality ratio. CI, 95% confidence interval. PDAC, pancreatic ductal adenocarcinoma; pNET, pancreatic neuroendocrine tumor; PCN, pancreatic cystic neoplasm. $ The chi-square test for linear trend was used for ordinal multi-categorical variables. # The Bonferroni-corrected P-value was used for multiple comparisons.