Table 1.
Clinical characterization of human subjects
| Control | SCD | |
|---|---|---|
| Female/male | 6/1 | 6/7 |
| Age, y | 44.29 (44; 32; 64) | 40.17 (40; 27; 59) |
| Hemoglobin (g/dL) | 13.14 (14; 11.4; 14.4) | 9.03 (8.7; 6.9; 13.5)* |
| Hematocrit (%) | 39.83 (41.8; 34.3; 43.9) | 26.33 (25.5; 20; 38.4)* |
| White blood cells (K/µL) | 5.78 (4.5; 3.9; 8.2) | 8.84 (8.9; 3.2; 16.1) |
| Neutrophils (K/µL) | 3.01 (2.97; 0.81; 4.64) | 4.98 (4.29; 1.47; 11.67) |
| Lymphocytes (K/µL) | 1.81 (2.38; 0.35; 2.71) | 2.68 (2.45; 0.26; 5.5) |
| Monocytes (K/µL) | 0.39 (0.36; 0.09; 0.66) | 0.77 (0.72; 0.05; 1.61) |
| Platelets (K/µL) | 234.4 (256; 143; 316) | 354.8 (400; 113; 702) |
| % HbS | NM | 67.94 (65.4; 50.3; 87.8) |
| % HbF | NM | 14.85 (12.4; 1.4; 35.4) |
| Genotypes | ||
| AA | 7 | 0 |
| AS | 0 | 0 |
| SS | 0 | 12 |
| S/β0 | 0 | 1 |
| Hydroxyurea (Y/N) | NA | 7/6 |
Data show mean (median; minimum; maximum) except for the sex, genotype, and hydroxyurea status.
AA, healthy control; AS, sickle cell trait; HbF, fetal hemoglobin; HbS, hemoglobin S; N, no; NM, not measured; S/β0, sickle β0 thalassemia; SS, sickle cell anemia; Y, yes.
*
P < .05.