Table 1.

Collection of data points in the trial

Data category	Baseline (enrolment)	Follow-up	8 weeks	12 weeks
Demographic and background information	Age, gender, education, marital status, occupation, socioeconomic status, health and prevention behaviours, COVID-19 vaccination (self-reported by participant, assessed by staff or abstracted from participant record)		COVID-19 vaccination (self-reported by participant)	COVID-19 vaccination (self-reported by participant)
Dietary information	Food frequency questionnaire: consumption frequency of 25 diverse food groups in last 3 months (self-reported by participant)
Clinical examination	Medical history, comorbidities, preadmission medications, non-intervention nutritional supplement use (self-reported by participant, assessed by staff or abstracted from participant record) Clinical symptoms* (Self-reported by participant)	Hospital and telephone follow-up: clinical symptoms* (self-reported by participant) Hospital follow-up only: changes in medications, changes in non-intervention nutritional supplement use (assessed by staff or abstracted from participant record)	Medical history, comorbidities, preassessment medications, non-intervention nutritional supplement use (Self-reported by participant, assessed by staff or abstracted from participant record) Clinical symptoms* (self-reported by participant)	Clinical symptoms* (Self-reported by participant)
Clinical measurements	Respiratory rate, pulse, auxiliary temperature, SpO2, systolic and diastolic blood pressure, weight and height (assessed by staff or abstracted from participant record)	Hospital follow-up only: Respiratory rate, pulse, auxiliary temperature, SpO2, systolic and diastolic blood pressure, weight, requirement for non-invasive ventilation or intubation/ventilator support, need for dialysis, lab investigations (assessed by staff or abstracted from participant record)	Respiratory rate, pulse, auxiliary temperature, SpO2, systolic and diastolic blood pressure, weight and height (assessed by staff or abstracted from participant record)
Blood and other investigations and biomarkers	SARS-CoV-2 RT-PCR, chest X-ray, complete blood count, blood glucose, serum creatinine, CRP, LDH, serum ferritin, D-dimer, vitamin D, zinc, calcium, IgG, IgM, Ang2, IL-6 and sTREM-1 (assessed by laboratory or abstracted from participant record)		CRP, LDH, serum ferritin, D-dimer, vitamin D, zinc, calcium, IgG, IgM, Ang2, IL-6 and sTREM-1 (assessed by laboratory or abstracted from participant record)
Other information		Hospital and telephone follow-up: compliance, adverse events (self-reported by participant, assessed by staff or abstracted from participant record)	Compliance (count of remaining pills) (assessed by staff)

*Clinical symptoms include: fever, cough, shortness of breath, fatigue, headache, loss of smell, loss of taste, diarrhoea, anorexia, sore throat, nasal congestion, nausea and vomiting, and any other reported by the participant.

Ang2, angiopoietin-2; CRP, C reactive protein; IL-6, interleukin 6; LDH, lactate dehydrogenase; SpO2, oxygen saturation; sTREM-1, soluble triggering receptor expressed on myeloid cells-1.