Table 1. Baseline clinical parameters based on DLCO < vs > 30% predicted.
| DLCO < 30% predicted | DLCO >30% predicted | |
|---|---|---|
| Number | 6 | 9 |
| Median (range) | Median (range) | |
| FVC, l | 1.20 (0.62-3.08) * | 2.17 (1.20-2.78) |
| FVC % predicted | 47 (27-68) | 58 (47-73) |
| FEV-1, l | 0.72 (0.45-1.59) | 0.94 (0.79-2.28) |
| FEV-1 % predicted | 29 (21-61) | 50 (25-70) |
| FEV-1/FVC % | 63 (37-81) | 68 (33-82) |
| DLCO, mm Hg § | 6.06 (3.78-21.00) | 11.52 (9.6-17.10) |
| DLCO % predicted † | 20.5 (19.0-29.0) | 56(31-70) |
| CPI † | 65.4 (57.0-72.8) | 43.61 (23.4-62.4) |
| 6MWD, m § | 190 (90-305) | 350 (183-454) |
| KSQ GH | 54 (49-100) | 62 (54-91) |
| KSQ_Lung | 54 (43-100) | 55 (40-65) |
| KBILD_Lung | 64 (44-100) | 64 (32-85) |
| KBILD_Total | 52 (38-78) | 53 (42-78) |
| MRC | 3(0-4) | 2 (1-4) |
| FAS | 21 (11-27) | 22 (11-36) |
| SF-36_Mental Health | 51 (16-65) | 70 (50-94) |
| SF-36_Physical Health | 31 (9-49) | 51 (21-83) |
| SF-36_Total | 42 (14-61) | 61 (42-87) |
| Female:Male | 4:2 | 5:4 |
| African American:Caucasian | 5:1 | 5:4 |
*Median (range)
§ Significant difference between groups, p<0.05
† Significant difference between groups, p<0.005;
FVC: forced vital capacity; FEV-1: forced expiratory volume in one second; DLCO: diffusion lung carbon monoxide; CPI: composite physiologic index; 6MWD: six minute walk distance; KSQ: King’s sarcoidosis questionnaire; KBILD: King’s Brief Interstitial Lung Disease questionnaire; FAS: fatigue assessment scale; SF-36: short form-36