Table 1. . Chemotherapy regimens.

First-line options:
FLOT	Oxaliplatin 85 mg/m2 i.v. on day 1 Docetaxel 50 mg/m2 i.v. on day 1 Leucovorin 200 mg/m2 i.v. on day 1 Fluorouracil 2600 mg/m2 continuous infusion over 24 h daily on day 1 Every 14 days
FOLFOX	Oxaliplatin 85 mg/m2 i.v. on day 1 Leucovorin 400 mg/m2 i.v. on day 1 Fluorouracil 400 mg/m2 i.v. push on day 1 Fluorouracil 1200 mg/m2 continuous infusion over 24 h daily on days 1 and 2 Every 14 days
Second-line options:
FOLFIRI	Irinotecan 180 mg/m2 i.v. on day 1 Leucovorin 400 mg/m2 i.v. on day 1 Fluorouracil 400 mg/m2 i.v. push on day 1 Fluorouracil 1200 mg/m2 continuous infusion over 24 h daily on days 1 and 2 Every 14 days
FOLFIRINOX	Oxaliplatin 85 mg/m2 i.v. on day 1 Irinotecan 150 mg/m2 i.v. on day 1 Leucovorin 200 mg/m2 i.v. on day 1 Fluorouracil 1200 mg/m2 continuous infusion over 24 h daily on days 1 and 2 Every 14 days
Paclitaxel with carboplatin	Paclitaxel 200 mg/m2 i.v. on day 1 Carboplatin AUC 5 i.v. on day 1 Every 21 days
Paclitaxel	Paclitaxel 80 mg/m2 i.v. on days 1, 8, 15 Every 28 days
Docetaxel and irinotecan†	Docetaxel 35 mg/m2 i.v. on days 1 and 8 Irinotecan 50 mg/m2 i.v. on days 1 and 8 Every 21 days
	Docetaxel 75 mg/m2 i.v. on day 1 Every 21 days
	Docetaxel 150 mg/m2 i.v. on day 1 Every 14 days
Additional therapy options:
Nivolumab‡	240 mg i.v. on day 1 every 14 days, or 360 mg i.v. on day 1 every 21 days, or 480 mg i.v. on day 1 every 28 days
Pembrolizumab‡	200 mg i.v. on day 1 every 21 days, or 400 mg i.v. on day 1 every 42 days

^†Alone or combined.

^‡Alone or when added to a regimen above.

AUC: Area under the curve; FLOT: 5FU, leucovorin, oxaliplatin and docetaxel; h: Hour; i.v.: Intravenously.