. 2022 Aug 17;29:749–768. doi: 10.1016/j.omtn.2022.08.018

Table 2.

Significant isoform switching without altered gene expression in BE.LGD TP53 WT versus BE.HGD TP53 MUT

Gene name	Isoform ID	dIF	FDR	Gene name	Isoform ID	dIF	FDR
MIR4458HG^a	ENST00000502001	0.326	<0.001	NEU4^a	ENST00000407683	−0.239	0.019
MIR4458HG^a	ENST00000652260	−0.355	<0.001	FSIP2-AS1	ENST00000429929	−0.152	0.019
MINDY1	ENST00000361936	−0.135	<0.001	AC015802.4	ENST00000592622	−0.200	0.019
MINDY1	ENST00000470877	0.100	<0.001	ALDH1A2	ENST00000558239	0.110	0.019
EVI2B	ENST00000330927	0.108	<0.001	PTRH1	ENST00000543175	0.202	0.019
EVI2B	ENST00000577894	−0.108	<0.001	ZNF324	ENST00000196482	0.136	0.020
CENPBD1P1	ENST00000493504	−0.103	<0.001	ZNF324	ENST00000593925	−0.126	0.034
CENPBD1P1	ENST00000651608	0.117	<0.001	GDF15^a	ENST00000252809	−0.145	0.020
AC234782.4^a	ENST00000674488	−0.259	<0.001	AC103810.1^a	ENST00000585187	−0.201	0.021
AC234782.4^a	ENST00000674271	0.248	0.024	PCSK5^a	ENST00000376752	0.134	0.022
LINC02615	ENST00000505133	0.110	<0.001	PCSK5^a	ENST00000674117	−0.147	0.023
LINC02615	ENST00000513851	−0.157	0.024	DCDC2	ENST00000378454	0.174	0.022
TSPAN6	ENST00000494424	−0.114	<0.001	DCDC2	ENST00000378450	−0.177	0.025
TSPAN6	ENST00000614008	0.108	0.021	LTB4R2	ENST00000527924	0.108	0.023
SMIM6	ENST00000556126	0.116	0.001	CRYBA2	ENST00000392096	−0.202	0.024
SMIM6	ENST00000579469	−0.116	0.001	GHR^a	ENST00000537449	−0.147	0.026
SESN1	ENST00000436639	−0.133	0.001	NEURL2	ENST00000545238	−0.240	0.028
TMED1	ENST00000588289	0.103	0.002	NEURL2	ENST00000372518	0.240	0.029
TMED1	ENST00000214869	−0.113	0.019	MSH5-SAPCD1	ENST00000476085	−0.137	0.028
AC026254.2	ENST00000666005	0.220	0.003	MSH5-SAPCD1	ENST00000493662	0.106	0.031
LINC00964	ENST00000657752	−0.128	0.005	TNNI1	ENST00000622580	−0.180	0.029
LINC00964	ENST00000663940	0.107	0.009	TNNI1	ENST00000555340	0.164	0.043
TMEM241	ENST00000577448	0.100	0.005	SFTA2	ENST00000634371	−0.113	0.030
TMEM241	ENST00000475185	0.128	0.029	SFTA2	ENST00000359086	0.106	0.037
PLA2G15	ENST00000562966	0.103	0.006	CCDC170	ENST00000537358	−0.269	0.030
PLA2G15	ENST00000219345	−0.115	0.044	TLCD1	ENST00000292090	0.153	0.031
ANKRD54	ENST00000609706	0.125	0.006	SOCS4	ENST00000395472	0.121	0.031
ZNF350^a	ENST00000243644	−0.138	0.009	AP000866.2^a	ENST00000504932	0.163	0.033
ZNF350^a	ENST00000599258	0.125	0.013	C1orf53	ENST00000436652	0.147	0.033
GAS2	ENST00000278187	0.155	0.009	TRIM29	ENST00000532195	−0.122	0.036
ATP9B	ENST00000586722	0.115	0.009	EFHC2	ENST00000420999	0.221	0.037
SPATA17	ENST00000470448	0.118	0.011	EFHC2	ENST00000343571	−0.221	0.038
SPATA17	ENST00000491809	−0.186	0.048	RSPH1^a	ENST00000291536	0.101	0.038
TMEM104^a	ENST00000335464	−0.182	0.011	CARNS1	ENST00000307823	−0.190	0.040
TMEM104^a	ENST00000584246	0.119	0.016	CFAP46^a	ENST00000486104	−0.132	0.041
COX19^a	ENST00000466146	0.117	0.012	CA4^a	ENST00000585705	0.147	0.041
WRAP53^a	ENST00000316024	0.126	0.014	ONECUT1	ENST00000305901	−0.219	0.043
WRAP53^a	ENST00000396463	−0.154	0.040	LINC00278	ENST00000652068	−0.135	0.043
DISP2^a	ENST00000559721	0.230	0.014	TMEM107	ENST00000437139	0.106	0.045
BCL7A	ENST00000432926	−0.197	0.015	ZBTB18	ENST00000622512	−0.102	0.046
BCL7A	ENST00000261822	0.160	0.039	ZBTB18	ENST00000358704	0.102	0.047
AC117453.1	ENST00000651749	−0.182	0.016	RTN2^a	ENST00000245923	−0.105	0.048
AC117453.1	ENST00000656199	0.151	0.021	LINC01186	ENST00000670979	0.115	0.049
SYT15	ENST00000449358	−0.138	0.017	CCDC190	ENST00000524710	−0.139	0.050
SYT15	ENST00000374321	0.131	0.026
S100A5	ENST00000368717	−0.247	0.017
S100A5	ENST00000368718	0.247	0.020

Genes shared between BE.LGD versus BE.HGD and BE.LGD TP53 WT versus BE.HGD TP53 MUT. BE.LGD: Barrett’s esophagus with metaplasia or low-grade dysplasia; BE.HGD: Barrett’s esophagus with high-grade dysplasia.