Table 2. NfL Classification Accuracy for ICANS Development at Different Time Points^a.

Time point	No.	ICANS, %	AUC	Sensitivity	Specificity
Baseline	30	37	0.96	0.91	0.95
Lymphodepletion	23	35	0.93	0.88	0.93
D1	24	38	0.87	0.89	0.87
D3	24	38	0.96	0.89	0.93
D7	24	38	0.84	0.67	0.93
D14	21	33	0.84	0.50	1.0
D30	21	40	0.88	0.57	1.0

Abbreviations: AUC, area under the ROC curve; ICANS, immune effector cell–associated neurotoxicity syndrome; NfL, neurofilament light chain; ROC, receiver operating characteristic.

^a The ROC classification of patients who develop any grade ICANS (≥1) vs no ICANS (grade 0) for NfL at each of the available time points. Baseline refers to prior to lymphodepletion, while lymphodepletion refers to blood draws obtained during lymphodepletion, but prior to chimeric antigen receptor infusion. D refers to the postinfusion day (eg, D1 is postinfusion day 1). Note that only a subset of samples were available for the later time points.