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. 2022 Aug 18;25(9):104955. doi: 10.1016/j.isci.2022.104955

Figure 3.

Figure 3

Prevalence of c/EBPα, SOX9 and TGFβ signaling in the adult liver and in reprogramming experiments

(A) Quantification of c/EBPα, SOX9, TGFBR2 expression levels along with activity of adult hepatocyte and adult biliary signatures in whole liver, EPCAM+, TROP2+, side cell populations and laser micro-dissected niche of adult liver stem cells via bulk RNA sequencing (GSE102683).

(B) Experimentally observed gene expression levels of c/EBPα, SOX9 and activity of TGFβ signaling in a population of hepatocytes, cholangiocytes and cholangiocytes derived from hepatocytes (GSE108315).

(C) Experimentally observed activity levels of TGFβ signaling, hepatocyte signature and SOX9 regulon activity in hepatocytes and oval cells derived from either hepatocytes or cholangiocytes (GSE55552).

(D) Experimentally observed activity levels of TGFβ signaling in several reprogrammed cells (GSE51791).

(E) c/EBPα regulon, SOX9 regulon and TGFβ signaling activity in hepatoblasts treated with miR-337 mimic showing a development toward cholangiocyte fate (GSE99890). ∗ represents a statistically significant difference in activity/expression levels (Students’ two-tailed t test; pvalue<= 0.05).