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. 2022 Aug 23;56:102446. doi: 10.1016/j.redox.2022.102446

Fig. 9.

Fig. 9

LDHA-driven lactate production induced M2 macrophage polarization.

(A) Arg1, CD206, CD38, MMP9 and iNOS protein levels in adult MI model after LDHA overexpression. n = 6 mice. (B) Flow cytometry analysis of macrophage polarization in adult MI model after LDHA overexpression. n = 5 mice. (C) Flow cytometry analysis of macrophage polarization in neonatal AR models after LDHA and sodium lactate interference. n = 5 mice. (D) Ki67 staining in neonatal AR models after LDHA interference and sodium lactate treatment (568 CMs from 15 images of 5 mice in Cre-empty + PBS, 590 CMs from 15 images of 5 mice in Cre-empty + Sodium lactate, 609 CMs from 15 images of 5 mice in Cre-LDHA + PBS and 592 CMs from 15 images of 5 mice in Cre-LDHA + Sodium lactate groups), bar = 20 μm (upper) and 10 μm (lower). Statistical significance was calculated using an unpaired t-test in A, two-way ANOVA in B and one-way ANOVA in C-D; *P < 0.05.